ENSMUSG00000035354


Mus musculus

Features
Gene ID: ENSMUSG00000035354
  
Biological name :Uvrag
  
Synonyms : Q8K245 / UV radiation resistance associated gene / Uvrag
  
Possible biological names infered from orthology : Q9P2Y5 / UV radiation resistance associated
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E1
Gene start: 98885021
Gene end: 99141141
  
Corresponding Affymetrix probe sets: 10565759 (MoGene1.0st)   1440427_at (Mouse Genome 430 2.0 Array)   1454706_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045297
Ensembl peptide - ENSMUSP00000146640
Ensembl peptide - ENSMUSP00000146336
NCBI entrez gene - 78610     See in Manteia.
MGI - MGI:1925860
RefSeq - NM_178635
RefSeq - XM_006508349
RefSeq Peptide - NP_848750
swissprot - A0A140LI21
swissprot - Q8K245
swissprot - A0A140LHA4
Ensembl - ENSMUSG00000035354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uvragENSDARG00000023815Danio rerio
 UVRAGENSGALG00000000845Gallus gallus
 UVRAGENSG00000198382Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018791  UV radiation resistance protein/autophagy-related protein 14
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007051 spindle organization IMP
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0032801 receptor catabolic process IEA
 biological_processGO:0035493 SNARE complex assembly IMP
 biological_processGO:0046718 viral entry into host cell IMP
 biological_processGO:0051684 maintenance of Golgi location IEA
 biological_processGO:0060627 regulation of vesicle-mediated transport IBA
 biological_processGO:0071900 regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0097680 double-strand break repair via classical nonhomologous end joining IEA
 cellular_componentGO:0000323 lytic vacuole IBA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0045335 phagocytic vesicle IPI
 cellular_componentGO:0070418 DNA-dependent protein kinase complex IEA
 molecular_functionGO:0000149 SNARE binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Agltm1a(EUCOMM)Wtsi/Agltm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / complex
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / complex






 

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