ENSMUSG00000029174


Mus musculus

Features
Gene ID: ENSMUSG00000029174
  
Biological name :Tbc1d1
  
Synonyms : Q60949 / Tbc1d1 / TBC1 domain family, member 1
  
Possible biological names infered from orthology : Q86TI0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 64156305
Gene end: 64351486
  
Corresponding Affymetrix probe sets: 10522024 (MoGene1.0st)   1419446_at (Mouse Genome 430 2.0 Array)   1419447_s_at (Mouse Genome 430 2.0 Array)   1419448_at (Mouse Genome 430 2.0 Array)   1447016_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119710
Ensembl peptide - ENSMUSP00000113643
Ensembl peptide - ENSMUSP00000143451
Ensembl peptide - ENSMUSP00000044577
Ensembl peptide - ENSMUSP00000098756
Ensembl peptide - ENSMUSP00000112493
NCBI entrez gene - 57915     See in Manteia.
MGI - MGI:1889508
RefSeq - XM_011240758
RefSeq - NM_001289514
RefSeq - NM_001310611
RefSeq - NM_019636
RefSeq - XM_006504036
RefSeq - XM_006504037
RefSeq - XM_006504038
RefSeq - XM_011240757
RefSeq Peptide - NP_062610
RefSeq Peptide - NP_001276443
RefSeq Peptide - NP_001297540
swissprot - Q3U3T9
swissprot - Q60949
swissprot - A0A0G2JG72
swissprot - F6QUA9
swissprot - E9Q6L4
Ensembl - ENSMUSG00000029174
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d1ENSDARG00000062081Danio rerio
 TBC1D1ENSGALG00000039380Gallus gallus
 Q86TI0ENSG00000065882Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbc1d4 / TBC1 domain family member 4 / O60343*ENSMUSG0000003308347
A2AWA9 / Rabgap1 / RAB GTPase activating protein 1 / Q9Y3P9*ENSMUSG0000003543717
A6H6A9 / Rabgap1l / Rab GTPase-activating protein 1-like / B7ZAP0* / Q5R372*ENSMUSG0000002672116
Tbc1d14 / TBC1 domain family, member 14 / Q9P2M4*ENSMUSG0000002919211
Evi5 / ecotropic viral integration site 5 / O60447*ENSMUSG0000001183110
Evi5l / Mus musculus ecotropic viral integration site 5 like (Evi5l), transcript variant 2, mRNA. / Q96CN4* / ecotropic viral integration site 5 like*ENSMUSG0000001183210
Tbc1d12 / TBC1 domain family member 12 / O60347*ENSMUSG000000487209


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR021785  Domain of unknown function DUF3350
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0090630 activation of GTPase activity IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012505 endomembrane system IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IBA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtf1Thyls-BALB/c/Mtf1Thyls-MSM
Genetic Background: involves: BALB/c * MSM

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ehmt1tm2Yshk/Ehmt1tm2Yshk,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mtf1Thyls-BALB/c/Mtf1Thyls-MSM
Genetic Background: involves: BALB/c * MSM

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
Genetic Background: C57BL/6J-Megf8b2b1702.2Clo

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnftm1Ljo/Tnf+,Tnip1tm1.1Ama/Tnip1tm1.1Ama
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Ljo/Tnf+,Tnip1tm1.1Ama/Tnip1tm1.1Ama
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnftm1Ljo/Tnf+,Tnip1tm1.1Ama/Tnip1tm1.1Ama
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0010951 abnormal lipid oxidation "anomaly in the process of removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0034440]
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction






 

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