ENSMUSG00000033083


Mus musculus

Features
Gene ID: ENSMUSG00000033083
  
Biological name :Tbc1d4
  
Synonyms : Tbc1d4 / TBC1 domain family member 4
  
Possible biological names infered from orthology : O60343
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E2.3
Gene start: 101442360
Gene end: 101609191
  
Corresponding Affymetrix probe sets: 10422028 (MoGene1.0st)   1435292_at (Mouse Genome 430 2.0 Array)   1455903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097913
Ensembl peptide - ENSMUSP00000124734
Ensembl peptide - ENSMUSP00000124909
Ensembl peptide - ENSMUSP00000125509
Ensembl peptide - ENSMUSP00000124511
NCBI entrez gene - 210789     See in Manteia.
MGI - MGI:2429660
RefSeq - XM_017315937
RefSeq - XM_006518762
RefSeq - XM_006518763
RefSeq - XM_006518764
RefSeq - XM_006518766
RefSeq - XM_011245002
RefSeq - XM_017315935
RefSeq - NM_001081278
RefSeq - XM_006518759
RefSeq - XM_006518760
RefSeq - XM_006518761
RefSeq Peptide - NP_001074747
swissprot - F6S7E8
swissprot - F6SUV7
swissprot - H7BX82
swissprot - E9Q6Q8
swissprot - E0CX53
Ensembl - ENSMUSG00000033083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d4ENSDARG00000075156Danio rerio
 TBC1D4ENSGALG00000016925Gallus gallus
 O60343ENSG00000136111Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60949 / Tbc1d1 / TBC1 domain family, member 1 / Q86TI0*ENSMUSG0000002917448
A2AWA9 / Rabgap1 / RAB GTPase activating protein 1 / Q9Y3P9*ENSMUSG0000003543717
A6H6A9 / Rabgap1l / Rab GTPase-activating protein 1-like / B7ZAP0* / Q5R372*ENSMUSG0000002672115
Evi5 / ecotropic viral integration site 5 / O60447*ENSMUSG0000001183111
Tbc1d14 / TBC1 domain family, member 14 / Q9P2M4*ENSMUSG0000002919210
Evi5l / Mus musculus ecotropic viral integration site 5 like (Evi5l), transcript variant 2, mRNA. / Q96CN4* / ecotropic viral integration site 5 like*ENSMUSG0000001183210
Tbc1d12 / TBC1 domain family member 12 / O60347*ENSMUSG000000487209


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR021785  Domain of unknown function DUF3350
 IPR033564  TBC1 domain family member 4
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0031339 negative regulation of vesicle fusion IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tlr7tm1Flv/Y
Genetic Background: involves: 129S1/Sv * C57BL/6 * MRL/Mp

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata2tm1.1Ebres/Gata2tm1.1Ebres
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0009300 increased parametrial fat pad weight 
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Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
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Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

Allelic Composition: Tbc1d4tm1.2Arte/Tbc1d4tm1.2Arte
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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