ENSMUSG00000042608


Mus musculus

Features
Gene ID: ENSMUSG00000042608
  
Biological name :Stk40
  
Synonyms : Q7TNL3 / Serine/threonine-protein kinase 40 / Stk40
  
Possible biological names infered from orthology : Q8N2I9 / serine/threonine kinase 40
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 126103957
Gene end: 126141029
  
Corresponding Affymetrix probe sets: 10508115 (MoGene1.0st)   1429650_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121674
Ensembl peptide - ENSMUSP00000092354
Ensembl peptide - ENSMUSP00000111990
Ensembl peptide - ENSMUSP00000114793
NCBI entrez gene - 74178     See in Manteia.
MGI - MGI:1921428
RefSeq - XM_017320414
RefSeq - NM_001145827
RefSeq - NM_028800
RefSeq - XM_006503441
RefSeq - XM_006503442
RefSeq Peptide - NP_083076
RefSeq Peptide - NP_001139299
swissprot - B1AW00
swissprot - Q7TNL3
swissprot - B1AVZ9
Ensembl - ENSMUSG00000042608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk40ENSDARG00000098135Danio rerio
 STK40ENSGALG00000032925Gallus gallus
 STK40ENSG00000196182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271520
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*ENSMUSG0000003250119
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*ENSMUSG0000002003218
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*ENSMUSG0000000977218
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSMUSG0000002851817
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*ENSMUSG0000002060117
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*ENSMUSG0000005069716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40
 IPR024236  Serine/threonine-protein kinase 40


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0005977 glycogen metabolic process IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043408 regulation of MAPK cascade IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0060425 lung morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0010899 abnormal pulmonary alveolar system morphology 
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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