ENSMUSG00000022553


Mus musculus

Features
Gene ID: ENSMUSG00000022553
  
Biological name :Maf1
  
Synonyms : Maf1 / Q9D0U6 / Repressor of RNA polymerase III transcription MAF1 homolog
  
Possible biological names infered from orthology : MAF1 homolog, negative regulator of RNA polymerase III / Q9H063
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 76351294
Gene end: 76354380
  
Corresponding Affymetrix probe sets: 10424833 (MoGene1.0st)   1420046_s_at (Mouse Genome 430 2.0 Array)   1420047_at (Mouse Genome 430 2.0 Array)   1451126_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023212
Ensembl peptide - ENSMUSP00000124242
Ensembl peptide - ENSMUSP00000124893
Ensembl peptide - ENSMUSP00000125387
Ensembl peptide - ENSMUSP00000124110
NCBI entrez gene - 68877     See in Manteia.
MGI - MGI:1916127
RefSeq - XM_006521339
RefSeq - NM_001164607
RefSeq - NM_001164608
RefSeq - NM_026859
RefSeq - XM_006521337
RefSeq - XM_006521338
RefSeq Peptide - NP_001158080
RefSeq Peptide - NP_081135
RefSeq Peptide - NP_001158079
swissprot - E0CYK4
swissprot - Q9D0U6
swissprot - E0CYF5
Ensembl - ENSMUSG00000022553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:112356ENSDARG00000036489Danio rerio
 MAF1ENSG00000179632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015257  Repressor of RNA polymerase III transcription Maf1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016480 negative regulation of transcription by RNA polymerase III IEA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030425 dendrite ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0060077 inhibitory synapse ISO
 molecular_functionGO:0000994 RNA polymerase III core binding IBA
 molecular_functionGO:0001030 RNA polymerase III type 1 promoter DNA binding ISO
 molecular_functionGO:0001031 RNA polymerase III type 2 promoter DNA binding ISO
 molecular_functionGO:0001032 RNA polymerase III type 3 promoter DNA binding ISO
 molecular_functionGO:0050811 GABA receptor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0003981 decreased circulating phospholipid level "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0010046 decreased omental fat pad weight "less than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0011590 increased hormone-sensitive lipase activity "greater ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate" [GO:0033878]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0020237 increased proline level "higher than normal concentration of proline and its metabolic derivatives, derived from the amino acid L-glutamate" [ISBN10:1572591536]
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction






 

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