ENSDARG00000053196


Danio rerio

Features
Gene ID: ENSDARG00000053196
  
Biological name :mtor
  
Synonyms : mechanistic target of rapamycin kinase / mtor
  
Possible biological names infered from orthology : P42345 / Q9JLN9 / Serine/threonine-protein kinase mTOR
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 46077609
Gene end: 46321918
  
Corresponding Affymetrix probe sets: Dr.2226.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000069674
Ensembl peptide - ENSDARP00000105458
NCBI entrez gene - 324254     See in Manteia.
RefSeq - NM_001077211
RefSeq Peptide - NP_001070679
swissprot - F1Q9H9
swissprot - B0UX67
ZFIN ID - ZDB-GENE-030131-2974
Ensembl - ENSDARG00000053196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTORENSGALG00000003339Gallus gallus
 MTORENSG00000198793Homo sapiens
 MtorENSMUSG00000028991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smg1 / SMG1 phosphatidylinositol 3-kinase-related kinase / Q8BKX6* / Q96Q15* / Serine/threonine-protein kinase SMG1 * / SMG1, nonsense mediated mRNA decay associated PI3K related kinase*ENSDARG0000005457017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR009076  FKBP12-rapamycin binding domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR024585  Domain of unknown function DUF3385, target of rapamycin protein
 IPR026683  Serine/threonine-protein kinase TOR


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031641 regulation of myelination IGI
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0032006 regulation of TOR signaling IGI
 biological_processGO:0043588 skin development IGI
 biological_processGO:0048565 digestive tract development IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord has fewer parts of type oligodendrocyte , abnormal
spinal cord central nervous system myelination decreased occurrence , abnormal
spinal cord oligodendrocyte decreased amount , abnormal
spinal cord myelin sheath decreased thickness , abnormal
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 ZFA:0000112 gut gut decreased size , abnormal
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 ZFA:0000123 liver liver decreased size , abnormal
liver low brightness , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased size , abnormal
whole organism decreased behavioural activity , abnormal
whole organism decreased amount , abnormal
whole organism cholesterol biosynthetic process decreased occurrence , abnormal
whole organism TOR signaling decreased occurrence , abnormal
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 ZFA:0001115 trunk trunk curved ventral , abnormal
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 ZFA:0001338 intestine intestine decreased size , abnormal
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 ZFA:0005123 gut epithelium gut epithelium morphology , abnormal
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 ZFA:0009078 gut endothelial cell gut endothelial cell morphology , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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