ENSMUSG00000040472


Mus musculus

Features
Gene ID: ENSMUSG00000040472
  
Biological name :Rabggta
  
Synonyms : Geranylgeranyl transferase type-2 subunit alpha / Q9JHK4 / Rabggta
  
Possible biological names infered from orthology : Q92696 / Rab geranylgeranyltransferase alpha subunit
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 55715416
Gene end: 55722263
  
Corresponding Affymetrix probe sets: 10420131 (MoGene1.0st)   1426046_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061498
Ensembl peptide - ENSMUSP00000128668
Ensembl peptide - ENSMUSP00000133032
Ensembl peptide - ENSMUSP00000154725
NCBI entrez gene - 56187     See in Manteia.
MGI - MGI:1860443
RefSeq - NM_019519
RefSeq - XM_006519294
RefSeq - XM_006519295
RefSeq Peptide - NP_062392
swissprot - Q9JHK4
Ensembl - ENSMUSG00000040472
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rabggtaENSDARG00000061024Danio rerio
 Q92696ENSG00000100949Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002088  Protein prenyltransferase, alpha subunit
 IPR009087  Rab geranylgeranyltransferase, alpha subunit, insert-domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032955  Geranylgeranyl transferase type-2 subunit alpha
 IPR036254  Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018342 protein prenylation IEA
 biological_processGO:0018344 protein geranylgeranylation IMP
 biological_processGO:0065003 protein-containing complex assembly IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005968 Rab-protein geranylgeranyltransferase complex IBA
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004663 Rab geranylgeranyltransferase activity IMP
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008318 protein prenyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0004725 decreased platelet serotonin level "reduced concentration of serotonin in the platelets; this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

Allelic Composition: Rabggtagm/Rabggta+
Genetic Background: C57BL/6J-Rabggtagm

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0014060 abnormal platelet alpha-granule morphology "any structural anomaly of the most abundant secretory organelle found in blood platelets, and which store adhesive molecules such as von Willebrand factor and fibrinogen, growth factors and inflammatory and angiogenic mediators, which play crucial roles in inflammatory responses and tumor genesis" [PMID:26391322]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0020432 decreased platelet dense granule number "decreased number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [orcid.org/0000-0003-4606-0597]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction / complex
 ENSMUSG00000038975 P53612 / Rabggtb / Rab geranylgeranyl transferase, b subunit / P53611* / Rab geranylgeranyltransferase beta subunit*  / reaction / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex / reaction






 

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