ENSMUSG00000025730


Mus musculus

Features
Gene ID: ENSMUSG00000025730
  
Biological name :Rab40c
  
Synonyms : Q8VHQ4 / Rab40c / Rab40C, member RAS oncogene family
  
Possible biological names infered from orthology : Q96S21
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25882114
Gene end: 25919727
  
Corresponding Affymetrix probe sets: 10449152 (MoGene1.0st)   1424331_at (Mouse Genome 430 2.0 Array)   1424332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127868
Ensembl peptide - ENSMUSP00000136612
Ensembl peptide - ENSMUSP00000132355
Ensembl peptide - ENSMUSP00000131055
Ensembl peptide - ENSMUSP00000130093
Ensembl peptide - ENSMUSP00000026826
Ensembl peptide - ENSMUSP00000127546
NCBI entrez gene - 224624     See in Manteia.
MGI - MGI:2183454
RefSeq - NM_139154
RefSeq Peptide - NP_631893
swissprot - E9PXR4
swissprot - Q0PD11
swissprot - E9Q7Y6
swissprot - Q8VHQ4
swissprot - E9Q0X8
swissprot - E9Q016
Ensembl - ENSMUSG00000025730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab40cENSDARG00000061208Danio rerio
 RAB40CENSGALG00000030481Gallus gallus
 Q96S21ENSG00000197562Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab40b / Rab40B, member RAS oncogene family / Q12829* / RAB40A* / Q8WXH6* / P0C0E4* / RAB40AL* / RAB40A like* / RAB40A, member RAS oncogene family*ENSMUSG0000002517078
Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*ENSMUSG0000002487029
Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*ENSMUSG0000002014928
Rab43 / Q8CG50 / RAB43, member RAS oncogene family / Q86YS6*ENSMUSG0000003005526
Rab19 / P35294 / Ras-related protein Rab-19 / A4D1S5* / RAB19, member RAS oncogene family*ENSMUSG0000002992325
Rab26 / Q504M8 / RAB26, member RAS oncogene family / Q9ULW5*ENSMUSG0000007965725
Rab37 / RAB37, member RAS oncogene family / Q96AX2*ENSMUSG0000002073225
Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*ENSMUSG0000002951824
Rab30 / Q923S9 / RAB30, member RAS oncogene family / Q15771*ENSMUSG0000003064323
O35963 / Rab33b / RAB33B, member RAS oncogene family / Q9H082*ENSMUSG0000002773923
P97950 / Rab33a / RAB33A, member RAS oncogene family / Q14088*ENSMUSG0000003110422


Protein motifs (from Interpro)
Interpro ID Name
 IPR001496  SOCS box domain
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036036  SOCS box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0072659 protein localization to plasma membrane IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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