ENSDARG00000002591


Danio rerio

Features
Gene ID: ENSDARG00000002591
  
Biological name :ruvbl1
  
Synonyms : ruvbl1 / RuvB-like AAA ATPase 1
  
Possible biological names infered from orthology : P60122 / Q9Y265 / RuvB-like protein 1
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 40832635
Gene end: 40841032
  
Corresponding Affymetrix probe sets: Dr.2083.1.S1_at (Zebrafish Array)   NM_173835_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000012488
NCBI entrez gene - 317679     See in Manteia.
RefSeq - NM_173835
RefSeq Peptide - NP_776196
swissprot - Q6IQT8
ZFIN ID - ZDB-GENE-030109-2
Ensembl - ENSDARG00000002591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RUVBL1ENSGALG00000005931Gallus gallus
 Q9Y265ENSG00000175792Homo sapiens
 P60122ENSMUSG00000030079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010339  TIP49, C-terminal
 IPR027238  RuvB-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0097255 R2TP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
UCH proteinases
Ub-specific processing proteases
DNA Damage Recognition in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle hypertrophic , abnormal
cardiac ventricle non-functional , abnormal
cardiac ventricle hyperplastic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0000047 peripheral olfactory organ peripheral olfactory organ motile cilium immobile , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros quality , abnormal
Show

 ZFA:0001094 whole organism whole organism bent , abnormal
whole organism necrotic , abnormal
whole organism decreased amount , abnormal
whole organism absent , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk curved ventral , abnormal
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 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
post-vent region curved ventral , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus cystic , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule motile cilium has fewer parts of type pronephric tubule inner dynein arm, abnormal
pronephric tubule motile cilium has fewer parts of type pronephric tubule outer dynein arm, abnormal
pronephric tubule motile cilium immobile , abnormal
pronephric tubule cytoplasm decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000043236 ccna1 / cyclin A1 / P78396* / Q61456*  / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / reaction / complex
 ENSDARG00000015315 psmc5 / proteasome 26S subunit, ATPase 5 / P62195* / P62196* / protease (prosome, macropain) 26S subunit, ATPase 5*  / complex
 ENSDARG00000100623 trrap / transformation/transcription domain-associated protein / Q9Y4A5*  / complex / reaction






 

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