ENSDARG00000031894


Danio rerio

Features
Gene ID: ENSDARG00000031894
  
Biological name :lef1
  
Synonyms : lef1 / lymphoid enhancer-binding factor 1
  
Possible biological names infered from orthology : P27782 / Q9UJU2
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 49814461
Gene end: 49905357
  
Corresponding Affymetrix probe sets: Dr.8286.1.S1_at (Zebrafish Array)   NM_131426_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000047875
Ensembl peptide - ENSDARP00000114249
Ensembl peptide - ENSDARP00000132999
NCBI entrez gene - 30701     See in Manteia.
RefSeq - NM_131426
RefSeq Peptide - NP_571501
swissprot - F6NVS9
swissprot - A0A0R4II86
swissprot - Q9W7C0
ZFIN ID - ZDB-GENE-990714-26
Ensembl - ENSDARG00000031894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEF1ENSGALG00000031960Gallus gallus
 LEF1ENSG00000138795Homo sapiens
 Lef1ENSMUSG00000027985Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tcf7l2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*ENSDARG0000000441561
Q9YHE8 / tcf7l1a / transcription factor 7 like 1a / TCF7L1* / Q9HCS4* / transcription factor 7 like 1*ENSDARG0000003815958
tcf7l1b / transcription factor 7 like 1b / Q9HCS4* / TCF7L1* / transcription factor 7 like 1*ENSDARG0000000736956
tcf7 / transcription factor 7 / P36402* / Q00417* / transcription factor 7, T cell specific*ENSDARG0000003867253


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028769  Lymphoid enhancer-binding factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IBA
 biological_processGO:0001649 osteoblast differentiation IBA
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IBA
 biological_processGO:0002040 sprouting angiogenesis IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0016202 regulation of striated muscle tissue development IBA
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0021861 forebrain radial glial cell differentiation IBA
 biological_processGO:0021873 forebrain neuroblast division IBA
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0021943 formation of radial glial scaffolds IBA
 biological_processGO:0021979 hypothalamus cell differentiation IMP
 biological_processGO:0022008 neurogenesis IGI
 biological_processGO:0022407 regulation of cell-cell adhesion IBA
 biological_processGO:0030223 neutrophil differentiation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0032696 negative regulation of interleukin-13 production IBA
 biological_processGO:0032713 negative regulation of interleukin-4 production IBA
 biological_processGO:0032714 negative regulation of interleukin-5 production IBA
 biological_processGO:0033333 fin development IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0033336 caudal fin development IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0042100 B cell proliferation IBA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:0046632 alpha-beta T cell differentiation IBA
 biological_processGO:0048069 eye pigmentation IBA
 biological_processGO:0048341 paraxial mesoderm formation IBA
 biological_processGO:0048747 muscle fiber development IMP
 biological_processGO:0048916 posterior lateral line development IMP
 biological_processGO:0048919 posterior lateral line neuromast development IMP
 biological_processGO:0048922 posterior lateral line neuromast deposition IMP
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060325 face morphogenesis IBA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IBA
 biological_processGO:0060784 regulation of cell proliferation involved in tissue homeostasis IMP
 biological_processGO:0061153 trachea gland development IBA
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IBA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IBA
 biological_processGO:0071895 odontoblast differentiation IBA
 biological_processGO:1900052 regulation of retinoic acid biosynthetic process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008301 DNA binding, bending ISS
 molecular_functionGO:0030331 estrogen receptor binding IBA
 molecular_functionGO:0035326 enhancer binding IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IPI
 molecular_functionGO:0045295 gamma-catenin binding IBA
 molecular_functionGO:0070016 armadillo repeat domain binding IBA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain wholly posterioralized , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus neuron morphology , abnormal
hypothalamus neuron decreased amount , abnormal
hypothalamus axon decreased amount , abnormal
hypothalamus posterior region decreased size , abnormal
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 ZFA:0000040 median fin fold median fin fold decreased size , abnormal
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 ZFA:0000075 spinal cord spinal cord physical object quality , abnormal
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 ZFA:0000100 cerebellum cerebellum physical object quality , abnormal
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 ZFA:0000101 diencephalon diencephalon dopaminergic neuron increased amount , abnormal
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 ZFA:0000108 fin fin decreased size , abnormal
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 ZFA:0000128 midbrain midbrain morphology , abnormal
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 ZFA:0000138 otic placode otic placode decreased size , abnormal
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 ZFA:0000152 retina retina immature , abnormal
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 ZFA:0000155 somite somite decreased amount , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve truncated , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion mislocalised , abnormal
dorsal root ganglion decreased amount , abnormal
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 ZFA:0000243 neuromast neuromast decreased distance neuromast , abnormal
neuromast has fewer parts of type neuromast hair cell , abnormal
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 ZFA:0000255 paraxial mesoderm paraxial mesoderm decreased size , abnormal
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 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
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 ZFA:0000694 ceratobranchial 5 tooth ceratobranchial 5 tooth decreased amount , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast mislocalised anteriorly , abnormal
posterior lateral line neuromast decreased amount , abnormal
posterior lateral line neuromast posterior-most region absent , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line truncated , abnormal
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 ZFA:0001058 caudal fin caudal fin aplastic , abnormal
caudal fin decreased length , abnormal
caudal fin absent , abnormal
caudal fin morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism decreased pigmentation , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head apoptotic , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region wholly ventralized , abnormal
post-vent region truncated , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium cell proliferation decreased process quality , abnormal
posterior lateral line primordium cell division decreased process quality , abnormal
posterior lateral line primordium increased length , abnormal
posterior lateral line primordium self-renewal , abnormal
posterior lateral line primordium has number of posterior lateral line primordium cell, ameliorated
posterior lateral line primordium has fewer parts of type posterior lateral line primordium cell, abnormal
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 ZFA:0001161 pectoral fin pectoral fin absent , abnormal
pectoral fin decreased size , abnormal
pectoral fin hypoplastic , abnormal
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 ZFA:0001162 anal fin anal fin decreased length , abnormal
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 ZFA:0001173 dorsal fin dorsal fin decreased length , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage morphology , abnormal
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 ZFA:0001550 caudal fin lepidotrichium caudal fin lepidotrichium hypoplastic , abnormal
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 ZFA:0001551 pectoral fin lepidotrichium pectoral fin lepidotrichium hypoplastic , abnormal
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 ZFA:0009004 trunk neural crest cell trunk neural crest cell decreased amount , abnormal
trunk neural crest cell positional polarity , abnormal
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 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000020201 cdc73 / cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) / Q6P1J9* / Q8JZM7* / Parafibromin * / cell division cycle 73*  / reaction / complex
 ENSDARG00000036772 pygo2 / pygopus homolog 2 (Drosophila) / Q9BRQ0* / pygopus 2* / pygopus family PHD finger 2*  / reaction / complex
 ENSDARG00000002591 ruvbl1 / RuvB-like AAA ATPase 1 / P60122* / Q9Y265* / RuvB-like protein 1*  / reaction / complex
 ENSDARG00000101717 sox17 / SRY (sex determining region Y)-box 17 / Q9H6I2* / SRY-box 17*  / reaction / complex
 ENSDARG00000055357 leo1 / Q6NYV9 / LEO1 homolog, Paf1/RNA polymerase II complex component / Q5XJE5* / Q8WVC0* / RNA polymerase-associated protein LEO1 *  / reaction / complex
 ENSDARG00000069006 tle3b / O13168 / transducin-like enhancer of split 3b / TLE3* / Q08122* / Q04726* / transducin like enhancer of split 3*  / complex / reaction
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / reaction / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000004588 sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *  / reaction / complex
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex
 ENSDARG00000077226 smarca4a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a / P51532* / Q3TKT4* / SMARCA4* / SWI/SNF related, matrix associated, actin depe...  / reaction / complex
 ENSDARG00000028793 nlk2 / nemo-like kinase, type 2 / NLK* / O54949* / Q9UBE8* / nemo like kinase* / Serine/threonine-protein kinase NLK *  / reaction
 ENSDARG00000055054 bcl9l / B cell CLL/lymphoma 9-like / Q67FY2* / Q86UU0* / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA.*  / reaction / complex
 ENSDARG00000036687 bcl9 / B cell CLL/lymphoma 9 / O00512* / Q9D219* / B-cell CLL/lymphoma 9 protein *  / reaction / complex
 ENSDARG00000100623 trrap / transformation/transcription domain-associated protein / Q9Y4A5*  / complex / reaction






 

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