ENSDARG00000028793


Danio rerio

Features
Gene ID: ENSDARG00000028793
  
Biological name :nlk2
  
Synonyms : nemo-like kinase, type 2 / nlk2
  
Possible biological names infered from orthology : nemo like kinase / NLK / O54949 / Q9UBE8 / Serine/threonine-protein kinase NLK
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 30157602
Gene end: 30301528
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000047247
Ensembl peptide - ENSDARP00000144969
Ensembl peptide - ENSDARP00000107617
NCBI entrez gene - 563460     See in Manteia.
RefSeq - NM_001113485
RefSeq Peptide - NP_001106957
swissprot - E7F1L8
swissprot - B3IWJ8
swissprot - A9ZMG5
ZFIN ID - ZDB-GENE-080320-1
Ensembl - ENSDARG00000028793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NLKENSGALG00000005699Gallus gallus
 NLKENSG00000087095Homo sapiens
 NlkENSMUSG00000017376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nlk1 / nemo-like kinase, type 1ENSDARG0000000656663
mapk7 / mitogen-activated protein kinase 7 / Q13164* / Q9WVS8*ENSDARG0000002311032
mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*ENSDARG0000007057329
mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*ENSDARG0000002755228
mapk6 / mitogen-activated protein kinase 6 / Q16659* / Q61532*ENSDARG0000003210324
mapk15 / mitogen-activated protein kinase 15 / Q80Y86* / Q8TD08*ENSDARG0000010082222
mapk4 / mitogen-activated protein kinase 4 / P31152* / Q6P5G0*ENSDARG0000011058122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0030901 midbrain development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Ca2+ pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / reaction
 ENSDARG00000028793 nlk2 / nemo-like kinase, type 2 / NLK* / O54949* / Q9UBE8* / nemo like kinase* / Serine/threonine-protein kinase NLK *  / complex / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / reaction






 

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