ENSG00000087095


Homo sapiens

Features
Gene ID: ENSG00000087095
  
Biological name :NLK
  
Synonyms : nemo like kinase / NLK / Q9UBE8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 28041737
Gene end: 28196381
  
Corresponding Affymetrix probe sets: 218318_s_at (Human Genome U133 Plus 2.0 Array)   222589_at (Human Genome U133 Plus 2.0 Array)   222590_s_at (Human Genome U133 Plus 2.0 Array)   238624_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464656
Ensembl peptide - ENSP00000384625
Ensembl peptide - ENSP00000433117
NCBI entrez gene - 51701     See in Manteia.
OMIM - 609476
RefSeq - XM_005257988
RefSeq - NM_016231
RefSeq Peptide - NP_057315
swissprot - J3QSE9
swissprot - A0A024QZ12
swissprot - Q9UBE8
swissprot - H0YD75
Ensembl - ENSG00000087095
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlk2ENSDARG00000028793Danio rerio
 NLKENSGALG00000005699Gallus gallus
 NlkENSMUSG00000017376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK7 / Q13164 / mitogen-activated protein kinase 7ENSG0000016648433
MAPK3 / P27361 / mitogen-activated protein kinase 3ENSG0000010288228
MAPK1 / P28482 / mitogen-activated protein kinase 1ENSG0000010003028
MAPK15 / Q8TD08 / mitogen-activated protein kinase 15ENSG0000018108524
MAPK6 / Q16659 / mitogen-activated protein kinase 6ENSG0000006995623
MAPK4 / P31152 / mitogen-activated protein kinase 4ENSG0000014163922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISS
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0042501 serine phosphorylation of STAT protein ISS
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050821 protein stabilization IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042169 SH2 domain binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ca2+ pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087095 NLK / Q9UBE8 / nemo like kinase  / complex / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction






 

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