ENSDARG00000055357


Danio rerio

Features
Gene ID: ENSDARG00000055357
  
Biological name :leo1
  
Synonyms : leo1 / LEO1 homolog, Paf1/RNA polymerase II complex component / Q6NYV9
  
Possible biological names infered from orthology : Q5XJE5 / Q8WVC0 / RNA polymerase-associated protein LEO1
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 39292911
Gene end: 39321484
  
Corresponding Affymetrix probe sets: Dr.11557.1.A1_at (Zebrafish Array)   Dr.24919.1.A1_s_at (Zebrafish Array)   NM_207067_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000072160
NCBI entrez gene - 404599     See in Manteia.
RefSeq - NM_207067
RefSeq Peptide - NP_996950
swissprot - Q6NYV9
ZFIN ID - ZDB-GENE-040426-2435
Ensembl - ENSDARG00000055357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEO1ENSGALG00000004696Gallus gallus
 LEO1ENSG00000166477Homo sapiens
 Leo1ENSMUSG00000042487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007149  Leo1-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0016570 histone modification IEA
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IMP
 biological_processGO:0021782 glial cell development IMP
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0050936 xanthophore differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IDA
 molecular_functionGO:1990269 RNA polymerase II C-terminal domain phosphoserine binding IBA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the beta-catenin:TCF transactivating complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle collapsed , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000075 spinal cord spinal cord oligodendrocyte decreased amount , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
Show

 ZFA:0000154 sinus venosus sinus venosus collapsed , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus collapsed , abnormal
Show

 ZFA:0001114 head head melanocyte decreased amount , abnormal
head xanthophore decreased amount , abnormal
head melanoblast decreased amount , abnormal
Show

 ZFA:0001115 trunk trunk melanocyte decreased amount , abnormal
trunk xanthophore decreased amount , abnormal
trunk melanoblast decreased amount , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage aplastic , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage aplastic , abnormal
Show

 ZFA:0001507 trabecula cranii trabecula cranii aplastic , abnormal
Show

 ZFA:0009076 oligodendrocyte oligodendrocyte morphology , abnormal
oligodendrocyte decreased amount , abnormal
Show

 ZFA:0009090 pigment cell pigment cell decreased amount , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
Show

 ZFA:0009147 glial cell (sensu Vertebrata) glial cell (sensu Vertebrata) absent , abnormal
Show

 ZFA:0009198 xanthophore xanthophore decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000020201 cdc73 / cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) / Q6P1J9* / Q8JZM7* / Parafibromin * / cell division cycle 73*  / complex / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / complex / reaction






 

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