ENSMUSG00000021611


Mus musculus

Features
Gene ID: ENSMUSG00000021611
  
Biological name :Tert
  
Synonyms : O70372 / telomerase reverse transcriptase / Tert
  
Possible biological names infered from orthology : O14746
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 73626911
Gene end: 73649843
  
Corresponding Affymetrix probe sets: 10406086 (MoGene1.0st)   1450254_at (Mouse Genome 430 2.0 Array)   1456941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152750
Ensembl peptide - ENSMUSP00000152835
Ensembl peptide - ENSMUSP00000022104
Ensembl peptide - ENSMUSP00000152646
NCBI entrez gene - 21752     See in Manteia.
MGI - MGI:1202709
RefSeq - XM_006517212
RefSeq - XM_006517213
RefSeq - XM_006517214
RefSeq - NM_009354
RefSeq - XM_006517211
RefSeq Peptide - NP_033380
swissprot - O70372
swissprot - A0A1Y7VMP5
swissprot - A0A1Y7VP11
Ensembl - ENSMUSG00000021611
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tertENSDARG00000042637Danio rerio
 TERTENSGALG00000013183Gallus gallus
 TERTENSG00000164362Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000477  Reverse transcriptase domain
 IPR003545  Telomerase reverse transcriptase
 IPR021891  Telomerase ribonucleoprotein complex - RNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001172 transcription, RNA-templated IEA
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process IEA
 biological_processGO:0007004 telomere maintenance via telomerase TAS
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0022616 DNA strand elongation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0030422 production of siRNA involved in RNA interference IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032774 RNA biosynthetic process IEA
 biological_processGO:0042635 positive regulation of hair cycle IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0070200 establishment of protein localization to telomere IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903620 positive regulation of transdifferentiation IEA
 biological_processGO:1903704 negative regulation of production of siRNA involved in RNA interference IEA
 biological_processGO:1904173 regulation of histone demethylase activity (H3-K4 specific) TAS
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904751 positive regulation of protein localization to nucleolus IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000648 positive regulation of stem cell proliferation IMP
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0000333 telomerase catalytic core complex IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031379 RNA-directed RNA polymerase complex IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:1990572 TERT-RMRP complex IEA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003720 telomerase activity TAS
 molecular_functionGO:0003721 telomerase RNA reverse transcriptase activity IEA
 molecular_functionGO:0003723 RNA binding IPI
 molecular_functionGO:0003964 RNA-directed DNA polymerase activity ISO
 molecular_functionGO:0003968 RNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity ISO
 molecular_functionGO:0042162 telomeric DNA binding IBA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IPI
 molecular_functionGO:0098680 template-free RNA nucleotidyltransferase IEA


Pathways (from Reactome)
Pathway description
Telomere Extension By Telomerase
Formation of the beta-catenin:TCF transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001272 increased metastatic potential 
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Tg(Pou4f3-cre)1Devet/0
Genetic Background: involves: 129 * 129S/SvEv

Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Tert+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Terttm2.1Sear/Terttm2.1Sear
Genetic Background: Not Specified

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * SPRET/Ei

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Terttm1Leah/Tert+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Terttm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2+,Traf3tm1Bal/Traf3tm1Bal
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Terttm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Terttm1Leah/Tert+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Uchl3tm1Tilg/Uchl3tm1Tilg
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2+,Traf3tm1Bal/Traf3tm1Bal
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkb2tm2Brv/Nfkb2+,Traf3tm1Bal/Traf3tm1Bal
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

Allelic Composition: Terttm1.1Phan/Terttm1.1Phan,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Paxxem1Spj/Paxxem1Spj,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Terttm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Tert+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Tert+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm2.1Rdp/Terttm2.1Rdp
Genetic Background: involves: C57BL/6

 MP:0010266 decreased liver tumor incidence "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm1Rdp/Terttm1Rdp
Genetic Background: B6.Cg-Terttm1Rdp

 MP:0011807 decreased lung fibroblast proliferation "reduction in the expansion rate of a lung fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Terttm1.1Phan/Terttm1.1Phan,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021611 Tert / O70372 / telomerase reverse transcriptase / O14746*  / reaction / complex
 ENSMUSG00000031403 Dkc1 / Q9ESX5 / H/ACA ribonucleoprotein complex subunit 4 / O60832* / dyskerin pseudouridine synthase 1*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex / reaction
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / reaction / complex
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / complex / reaction






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr