ENSDARG00000042637


Danio rerio

Features
Gene ID: ENSDARG00000042637
  
Biological name :tert
  
Synonyms : telomerase reverse transcriptase / tert
  
Possible biological names infered from orthology : O14746 / O70372
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 627899
Gene end: 642878
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124691
Ensembl peptide - ENSDARP00000124988
Ensembl peptide - ENSDARP00000124558
NCBI entrez gene - 796551     See in Manteia.
RefSeq - NM_001083866
RefSeq Peptide - NP_001077335
swissprot - F8W2L0
swissprot - F1QE52
swissprot - F8W2Z1
ZFIN ID - ZDB-GENE-080405-1
Ensembl - ENSDARG00000042637
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TERTENSGALG00000013183Gallus gallus
 TERTENSG00000164362Homo sapiens
 TertENSMUSG00000021611Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000477  Reverse transcriptase domain
 IPR003545  Telomerase reverse transcriptase
 IPR021891  Telomerase ribonucleoprotein complex - RNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007004 telomere maintenance via telomerase IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007571 age-dependent general metabolic decline IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0043249 erythrocyte maturation IMP
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 cellular_componentGO:0000333 telomerase catalytic core complex IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003720 telomerase activity IMP
 molecular_functionGO:0003721 telomerase RNA reverse transcriptase activity IBA
 molecular_functionGO:0003964 RNA-directed DNA polymerase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IBA
 molecular_functionGO:0070034 telomerase RNA binding IBA


Pathways (from Reactome)
Pathway description
Telomere Extension By Telomerase
Formation of the beta-catenin:TCF transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord curvature , abnormal
Show

 ZFA:0000112 gut gut increased amount , abnormal
gut chromosome, telomeric region decreased length , abnormal
gut cell proliferation decreased occurrence , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer disorganized , abnormal
retinal photoreceptor layer atrophied , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium decreased thickness , abnormal
Show

 ZFA:0000152 retina retina degeneration , abnormal
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 ZFA:0000242 male organism male organism decreased fertility , abnormal
male organism has fewer parts of type head kidney renal tubule, abnormal
male organism has fewer parts of type head kidney hematopoietic multipotent progenitor cell, abnormal
male organism gut increased thickness , abnormal
male organism gut apoptotic , abnormal
male organism gut degenerate , abnormal
male organism gut senescent , abnormal
male organism gut inflammatory , abnormal
male organism liver degenerate , abnormal
male organism trunk musculature degenerate , abnormal
male organism head kidney apoptotic , abnormal
male organism head kidney degenerate , abnormal
male organism head kidney senescent , abnormal
male organism renal tubule apoptotic , abnormal
male organism intestinal epithelium dysplastic , abnormal
male organism intestinal villus decreased length , abnormal
male organism blood cell decreased amount , abnormal
male organism hematopoietic multipotent progenitor cell apoptotic , abnormal
Show

 ZFA:0000303 female organism female organism decreased fertility , abnormal
Show

 ZFA:0000368 integument integument chromosome, telomeric region decreased length , abnormal
Show

 ZFA:0000598 testis testis atrophied , abnormal
testis telomere maintenance decreased occurrence , abnormal
testis apoptotic , abnormal
testis degenerate , abnormal
testis senescent , abnormal
testis sperm decreased amount , abnormal
testis germ line cell apoptotic , abnormal
testis increased amount , abnormal
testis chromosome, telomeric region decreased length , abnormal
testis cell proliferation decreased occurrence , abnormal
testis germ cell tumor increased amount , abnormal
Show

 ZFA:0000669 head kidney head kidney increased amount , abnormal
head kidney cell proliferation decreased occurrence , abnormal
head kidney nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0001058 caudal fin caudal fin bent , abnormal
caudal fin chromosome, telomeric region decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased female fertility , abnormal
whole organism decreased male fertility , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism viability , abnormal
whole organism decreased size , abnormal
whole organism decreased life span , abnormal
whole organism deformed , abnormal
whole organism chromosome, telomeric region physical object quality , abnormal
whole organism hypoplastic , abnormal
whole organism atrophied , abnormal
whole organism nuclear chromosome, telomeric region decreased length , abnormal
whole organism decreased weight , abnormal
whole organism degeneration , abnormal
whole organism neoplasm increased amount , abnormal
Show

 ZFA:0001114 head head apoptotic , abnormal
Show

 ZFA:0001115 trunk trunk apoptotic , abnormal
trunk curved , abnormal
Show

 ZFA:0001135 neural tube neural tube closure incomplete , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus apoptotic , abnormal
Show

 ZFA:0001655 pericardial cavity pericardial cavity edematous , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta apoptotic , abnormal
Show

 ZFA:0005123 gut epithelium gut epithelium chromosome, telomeric region decreased length , abnormal
gut epithelium chromosome, telomeric region decreased variability of size , abnormal
Show

 ZFA:0005145 muscle muscle increased amount , abnormal
muscle chromosome, telomeric region decreased length , abnormal
Show

 ZFA:0005659 intestinal lamina propria mucosa intestinal lamina propria mucosa leukocyte migration involved in inflammatory response increased occurrence , abnormal
Show

 ZFA:0009000 cell cell chromosome, telomeric region decreased length , abnormal
Show

 ZFA:0009006 sperm sperm decreased amount , abnormal
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
blood cell absent , abnormal
blood cell apoptotic , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte vacuolated , abnormal
Show

 ZFA:0009114 muscle cell muscle cell atrophied , abnormal
muscle cell degeneration , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte immature , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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