ENSMUSG00000063382


Mus musculus

Features
Gene ID: ENSMUSG00000063382
  
Biological name :Bcl9l
  
Synonyms : Bcl9l / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA. / Q67FY2
  
Possible biological names infered from orthology : B cell CLL/lymphoma 9 like / Q86UU0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 44482825
Gene end: 44511896
  
Corresponding Affymetrix probe sets: 10584762 (MoGene1.0st)   1419180_at (Mouse Genome 430 2.0 Array)   1438806_at (Mouse Genome 430 2.0 Array)   1443700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074516
Ensembl peptide - ENSMUSP00000151342
Ensembl peptide - ENSMUSP00000151653
Ensembl peptide - ENSMUSP00000151837
NCBI entrez gene - 80288     See in Manteia.
MGI - MGI:1933114
RefSeq - XM_017313700
RefSeq - NM_001357490
RefSeq - NM_030256
RefSeq - XM_006510702
RefSeq - XM_006510703
RefSeq - XM_006510704
RefSeq - XM_006510705
RefSeq - XM_006510700
RefSeq - XM_006510701
RefSeq Peptide - NP_001344419
RefSeq Peptide - NP_084532
swissprot - Q67FY2
swissprot - A0A1W2P7G4
Ensembl - ENSMUSG00000063382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl9lENSDARG00000055054Danio rerio
 BCL9LENSGALG00000007685Gallus gallus
 BCL9LENSG00000186174Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl9 / Q9D219 / B-cell CLL/lymphoma 9 protein / O00512* / B cell CLL/lymphoma 9*ENSMUSG0000003825634


Protein motifs (from Interpro)
Interpro ID Name
 IPR015668  B Cell Lymphoma 9
 IPR024670  B-cell lymphoma 9, beta-catenin binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0022604 regulation of cell morphogenesis ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0035019 somatic stem cell population maintenance IGI
 biological_processGO:0035914 skeletal muscle cell differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:1990907 beta-catenin-TCF complex IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex
 ENSMUSG00000034910 Pygo1 / Q9D0P5 / pygopus 1 / Q9Y3Y4* / pygopus family PHD finger 1*  / complex / reaction
 ENSMUSG00000047824 Pygo2 / pygopus 2 / Q9BRQ0* / pygopus family PHD finger 2*  / reaction / complex






 

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