ENSMUSG00000038256


Mus musculus

Features
Gene ID: ENSMUSG00000038256
  
Biological name :Bcl9
  
Synonyms : B-cell CLL/lymphoma 9 protein / Bcl9 / Q9D219
  
Possible biological names infered from orthology : B cell CLL/lymphoma 9 / O00512
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 97203662
Gene end: 97297917
  
Corresponding Affymetrix probe sets: 10500434 (MoGene1.0st)   1451574_at (Mouse Genome 430 2.0 Array)   1455565_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046152
Ensembl peptide - ENSMUSP00000131692
NCBI entrez gene - 77578     See in Manteia.
MGI - MGI:1924828
RefSeq - XM_006502292
RefSeq - NM_029933
RefSeq - XM_006502290
RefSeq - XM_006502291
RefSeq - XM_006502288
RefSeq - XM_006502289
RefSeq Peptide - NP_084209
swissprot - Q9D219
Ensembl - ENSMUSG00000038256
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl9ENSDARG00000036687Danio rerio
 BCL9ENSGALG00000037655Gallus gallus
 BCL9ENSG00000116128Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl9l / Q67FY2 / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA. / Q86UU0* / B cell CLL/lymphoma 9 like*ENSMUSG0000006338236


Protein motifs (from Interpro)
Interpro ID Name
 IPR015668  B Cell Lymphoma 9
 IPR024670  B-cell lymphoma 9, beta-catenin binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014908 myotube differentiation involved in skeletal muscle regeneration IGI
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035019 somatic stem cell population maintenance IGI
 biological_processGO:0035914 skeletal muscle cell differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005801 cis-Golgi network ISO
 cellular_componentGO:1990907 beta-catenin-TCF complex ISO
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0008013 beta-catenin binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl9tm1.1Agt/Bcl9tm1.1Agt,Bcl9ltm1.1Agt/Bcl9ltm1.1Agt,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction
 ENSMUSG00000034910 Pygo1 / Q9D0P5 / pygopus 1 / Q9Y3Y4* / pygopus family PHD finger 1*  / reaction / complex
 ENSMUSG00000047824 Pygo2 / pygopus 2 / Q9BRQ0* / pygopus family PHD finger 2*  / complex / reaction






 

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