ENSMUSG00000034910


Mus musculus

Features
Gene ID: ENSMUSG00000034910
  
Biological name :Pygo1
  
Synonyms : Pygo1 / pygopus 1 / Q9D0P5
  
Possible biological names infered from orthology : pygopus family PHD finger 1 / Q9Y3Y4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 72925645
Gene end: 72952181
  
Corresponding Affymetrix probe sets: 10586993 (MoGene1.0st)   1431091_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044368
NCBI entrez gene - 72135     See in Manteia.
MGI - MGI:1919385
RefSeq - NM_028116
RefSeq Peptide - NP_082392
swissprot - Q1JPR5
swissprot - Q9D0P5
Ensembl - ENSMUSG00000034910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pygo1ENSDARG00000098687Danio rerio
 PYGO1ENSGALG00000004369Gallus gallus
 PYGO1ENSG00000171016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pygo2 / pygopus 2 / Q9BRQ0* / pygopus family PHD finger 2*ENSMUSG0000004782434


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0007286 spermatid development IGI
 biological_processGO:0007289 spermatid nucleus differentiation IGI
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pygo1tm1.1Ssp/Pygo1+,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hesx1tm1Icar/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm3.1Hhf/Nlrp3+
Genetic Background: involves: 129

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1tm1.1Ssp,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex
 ENSMUSG00000038256 Bcl9 / Q9D219 / B-cell CLL/lymphoma 9 protein / O00512* / B cell CLL/lymphoma 9*  / reaction / complex
 ENSMUSG00000063382 Bcl9l / Q67FY2 / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA. / Q86UU0* / B cell CLL/lymphoma 9 like*  / complex / reaction






 

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