ENSG00000106829


Homo sapiens

Features
Gene ID: ENSG00000106829
  
Biological name :TLE4
  
Synonyms : Q04727 / TLE4 / transducin like enhancer of split 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.31
Gene start: 79571773
Gene end: 79726882
  
Corresponding Affymetrix probe sets: 204872_at (Human Genome U133 Plus 2.0 Array)   214688_at (Human Genome U133 Plus 2.0 Array)   216997_x_at (Human Genome U133 Plus 2.0 Array)   233575_s_at (Human Genome U133 Plus 2.0 Array)   235765_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417844
Ensembl peptide - ENSP00000417715
Ensembl peptide - ENSP00000417906
Ensembl peptide - ENSP00000418409
Ensembl peptide - ENSP00000265284
Ensembl peptide - ENSP00000365720
Ensembl peptide - ENSP00000365727
Ensembl peptide - ENSP00000365735
Ensembl peptide - ENSP00000397822
Ensembl peptide - ENSP00000400334
Ensembl peptide - ENSP00000409313
Ensembl peptide - ENSP00000412567
Ensembl peptide - ENSP00000415423
Ensembl peptide - ENSP00000417102
Ensembl peptide - ENSP00000417245
NCBI entrez gene - 7091     See in Manteia.
OMIM - 605132
RefSeq - XM_017015086
RefSeq - XM_017015069
RefSeq - XM_017015070
RefSeq - XM_017015071
RefSeq - XM_017015072
RefSeq - XM_017015073
RefSeq - XM_017015074
RefSeq - XM_017015075
RefSeq - XM_017015076
RefSeq - XM_017015077
RefSeq - XM_017015078
RefSeq - XM_017015079
RefSeq - XM_017015080
RefSeq - XM_017015081
RefSeq - XM_017015082
RefSeq - XM_017015083
RefSeq - XM_017015084
RefSeq - XM_017015085
RefSeq - NM_001282748
RefSeq - NM_001282749
RefSeq - NM_001282753
RefSeq - NM_001282760
RefSeq - NM_007005
RefSeq - XM_005252177
RefSeq - XM_006717264
RefSeq - XM_006717268
RefSeq - XM_011518952
RefSeq - XM_011518953
RefSeq - XM_011518954
RefSeq - XM_011518955
RefSeq - XM_011518956
RefSeq - XM_011518957
RefSeq - XM_011518958
RefSeq - XM_011518959
RefSeq - XM_011518960
RefSeq - XM_011518961
RefSeq - XM_011518962
RefSeq - XM_011518963
RefSeq - XM_011518964
RefSeq - XM_011518965
RefSeq - XM_011518966
RefSeq - XM_011518967
RefSeq - XM_011518968
RefSeq - XM_011518969
RefSeq - XM_011518970
RefSeq - XM_017015067
RefSeq - XM_017015068
RefSeq Peptide - NP_001269678
RefSeq Peptide - NP_001269682
RefSeq Peptide - NP_001269689
RefSeq Peptide - NP_008936
RefSeq Peptide - NP_001269677
swissprot - H7C4W5
swissprot - Q5JSY7
swissprot - Q5JSY8
swissprot - Q5JSZ1
swissprot - Q5JSZ2
swissprot - A0A0A0MT79
swissprot - E7EQH3
swissprot - Q04727
swissprot - F8WAY5
swissprot - H0Y5S0
swissprot - H7C4E4
swissprot - H7C4P7
Ensembl - ENSG00000106829
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE4Z1ENSGALG00000015184Gallus gallus
 Tle4ENSMUSG00000024642Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE1 / Q04724 / transducin like enhancer of split 1ENSG0000019678183
TLE3 / Q04726 / transducin like enhancer of split 3ENSG0000014033279
TLE2 / Q04725 / transducin like enhancer of split 2ENSG0000006571764
TLE6 / Q9H808 / transducin like enhancer of split 6ENSG0000010495319
TLE7 / transducin like enhancer of split family member 7ENSG0000026073418
AES / Q08117 / amino-terminal enhancer of splitENSG0000010496417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:1990907 beta-catenin-TCF complex IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction / complex
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / complex / reaction
 ENSG00000104964 AES / Q08117 / amino-terminal enhancer of split  / reaction / complex
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / complex / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / reaction
 ENSG00000114315 HES1 / Q14469 / hes family bHLH transcription factor 1  / reaction / complex
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / reaction
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction






 

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