ENSG00000104964


Homo sapiens

Features
Gene ID: ENSG00000104964
  
Biological name :AES
  
Synonyms : AES / amino-terminal enhancer of split / Q08117
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 3052910
Gene end: 3063107
  
Corresponding Affymetrix probe sets: 217729_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000317537
Ensembl peptide - ENSP00000466179
Ensembl peptide - ENSP00000467831
Ensembl peptide - ENSP00000221561
Ensembl peptide - ENSP00000466038
NCBI entrez gene - 166     See in Manteia.
OMIM - 600188
RefSeq - XM_006722664
RefSeq - NM_001130
RefSeq - NM_198969
RefSeq - NM_198970
RefSeq Peptide - NP_945320
RefSeq Peptide - NP_001121
RefSeq Peptide - NP_945321
swissprot - Q08117
swissprot - K7ELQ8
swissprot - K7ELE3
swissprot - K7EQH5
Ensembl - ENSG00000104964
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aesENSDARG00000021805Danio rerio
 chicoENSDARG00000019588Danio rerio
 AESENSGALG00000029503Gallus gallus
 AesENSMUSG00000054452Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE4 / Q04727 / transducin like enhancer of split 4ENSG0000010682952
TLE1 / Q04724 / transducin like enhancer of split 1ENSG0000019678149
TLE3 / Q04726 / transducin like enhancer of split 3ENSG0000014033247
TLE2 / Q04725 / transducin like enhancer of split 2ENSG0000006571746
TLE6 / Q9H808 / transducin like enhancer of split 6ENSG000001049538
TLE7 / transducin like enhancer of split family member 7ENSG000002607346


Protein motifs (from Interpro)
Interpro ID Name
 IPR005617  Groucho/TLE, N-terminal Q-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0060761 negative regulation of response to cytokine stimulus IMP
 biological_processGO:0070555 response to interleukin-1 IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:2000210 positive regulation of anoikis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003714 transcription corepressor activity IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / reaction / complex
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / complex / reaction
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / reaction / complex
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / complex / reaction






 

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