ENSG00000196781


Homo sapiens

Features
Gene ID: ENSG00000196781
  
Biological name :TLE1
  
Synonyms : Q04724 / TLE1 / transducin like enhancer of split 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q21.32
Gene start: 81583683
Gene end: 81689305
  
Corresponding Affymetrix probe sets: 1553569_at (Human Genome U133 Plus 2.0 Array)   1553570_x_at (Human Genome U133 Plus 2.0 Array)   203220_s_at (Human Genome U133 Plus 2.0 Array)   203221_at (Human Genome U133 Plus 2.0 Array)   203222_s_at (Human Genome U133 Plus 2.0 Array)   227130_s_at (Human Genome U133 Plus 2.0 Array)   228284_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365646
Ensembl peptide - ENSP00000365667
Ensembl peptide - ENSP00000365682
Ensembl peptide - ENSP00000391347
NCBI entrez gene - 7088     See in Manteia.
OMIM - 600189
RefSeq - XM_017015066
RefSeq - NM_001303103
RefSeq - NM_001303104
RefSeq - NM_005077
RefSeq - XM_006717260
RefSeq - XM_006717261
RefSeq - XM_006717262
RefSeq - XM_006717263
RefSeq - XM_011518951
RefSeq - XM_017015064
RefSeq - XM_017015065
RefSeq - XM_005252151
RefSeq - XM_005252152
RefSeq - XM_005252153
RefSeq - XM_005252154
RefSeq - XM_005252156
RefSeq - XM_005252162
RefSeq - XM_005252163
RefSeq - XM_006717258
RefSeq - XM_006717259
RefSeq Peptide - NP_001290032
RefSeq Peptide - NP_001290033
RefSeq Peptide - NP_005068
swissprot - Q04724
swissprot - Q5T3G2
swissprot - Q5T3G3
swissprot - F6T2C8
Ensembl - ENSG00000196781
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLE1ENSGALG00000012575Gallus gallus
 Tle1ENSMUSG00000008305Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLE4 / Q04727 / transducin like enhancer of split 4ENSG0000010682987
TLE3 / Q04726 / transducin like enhancer of split 3ENSG0000014033280
TLE2 / Q04725 / transducin like enhancer of split 2ENSG0000006571767
TLE6 / Q9H808 / transducin like enhancer of split 6ENSG0000010495319
TLE7 / transducin like enhancer of split family member 7ENSG0000026073418
AES / Q08117 / amino-terminal enhancer of splitENSG0000010496417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR005617  Groucho/TLE, N-terminal Q-rich domain
 IPR009146  Groucho/transducin-like enhancer
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway NAS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 biological_processGO:2000811 negative regulation of anoikis IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IMP
 cellular_componentGO:1990907 beta-catenin-TCF complex IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106829 TLE4 / Q04727 / transducin like enhancer of split 4  / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / complex / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / complex / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction / complex
 ENSG00000140332 TLE3 / Q04726 / transducin like enhancer of split 3  / reaction
 ENSG00000114315 HES1 / Q14469 / hes family bHLH transcription factor 1  / complex / reaction
 ENSG00000104964 AES / Q08117 / amino-terminal enhancer of split  / reaction / complex
 ENSG00000196781 TLE1 / Q04724 / transducin like enhancer of split 1  / reaction / complex
 ENSG00000065717 TLE2 / Q04725 / transducin like enhancer of split 2  / reaction






 

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