ENSG00000069812


Homo sapiens

Features
Gene ID: ENSG00000069812
  
Biological name :HES2
  
Synonyms : HES2 / hes family bHLH transcription factor 2 / Q9Y543
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.31
Gene start: 6412418
Gene end: 6424670
  
Corresponding Affymetrix probe sets: 214521_at (Human Genome U133 Plus 2.0 Array)   216674_at (Human Genome U133 Plus 2.0 Array)   231928_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465248
Ensembl peptide - ENSP00000465270
Ensembl peptide - ENSP00000367065
Ensembl peptide - ENSP00000367067
Ensembl peptide - ENSP00000367068
NCBI entrez gene - 54626     See in Manteia.
OMIM - 609970
RefSeq - NM_019089
RefSeq Peptide - NP_061962
swissprot - K7EJN2
swissprot - K7EJQ0
swissprot - Q9Y543
Ensembl - ENSG00000069812
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hes2.1ENSDARG00000074897Danio rerio
 hes2.2ENSDARG00000068168Danio rerio
 Hes2ENSMUSG00000028940Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HES4 / Q9HCC6 / hes family bHLH transcription factor 4ENSG0000018829046
HES1 / Q14469 / hes family bHLH transcription factor 1ENSG0000011431542
HES6 / Q96HZ4 / hes family bHLH transcription factor 6ENSG0000014448529


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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