ENSG00000144485


Homo sapiens

Features
Gene ID: ENSG00000144485
  
Biological name :HES6
  
Synonyms : HES6 / hes family bHLH transcription factor 6 / Q96HZ4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.3
Gene start: 238238267
Gene end: 238240662
  
Corresponding Affymetrix probe sets: 226446_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387215
Ensembl peptide - ENSP00000401797
Ensembl peptide - ENSP00000392596
Ensembl peptide - ENSP00000390870
Ensembl peptide - ENSP00000387343
Ensembl peptide - ENSP00000272937
Ensembl peptide - ENSP00000387008
Ensembl peptide - ENSP00000387107
Ensembl peptide - ENSP00000387155
NCBI entrez gene - 55502     See in Manteia.
OMIM - 610331
RefSeq - NM_018645
RefSeq - NM_001142853
RefSeq - NM_001282434
RefSeq Peptide - NP_001269363
RefSeq Peptide - NP_001136325
RefSeq Peptide - NP_061115
swissprot - Q96HZ4
swissprot - B9A070
swissprot - B8ZZP9
swissprot - H7C020
swissprot - H7C1R4
swissprot - C9JF41
Ensembl - ENSG00000144485
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 her13ENSDARG00000007097Danio rerio
 ENSGALG00000028415Gallus gallus
 Hes6ENSMUSG00000067071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HES1 / Q14469 / hes family bHLH transcription factor 1ENSG0000011431527
HES4 / Q9HCC6 / hes family bHLH transcription factor 4ENSG0000018829026
HES2 / Q9Y543 / hes family bHLH transcription factor 2ENSG0000006981222


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003712 transcription coregulator activity ISS
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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