ENSMUSG00000030739


Mus musculus

Features
Gene ID: ENSMUSG00000030739
  
Biological name :Myh14
  
Synonyms : Myh14 / Myosin-14 / Q6URW6
  
Possible biological names infered from orthology : myosin heavy chain 14 / Q7Z406
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44605803
Gene end: 44670843
  
Corresponding Affymetrix probe sets: 10562856 (MoGene1.0st)   1428835_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046059
Ensembl peptide - ENSMUSP00000146584
Ensembl peptide - ENSMUSP00000147115
Ensembl peptide - ENSMUSP00000146686
Ensembl peptide - ENSMUSP00000103531
Ensembl peptide - ENSMUSP00000103532
NCBI entrez gene - 71960     See in Manteia.
MGI - MGI:1919210
RefSeq - XM_011250902
RefSeq - XM_017312313
RefSeq - XM_011250903
RefSeq - NM_001271538
RefSeq - NM_001271540
RefSeq - NM_028021
RefSeq Peptide - NP_001258467
RefSeq Peptide - NP_001258469
RefSeq Peptide - NP_082297
swissprot - Q6URW6
swissprot - A0A140LI60
swissprot - A0A140LHX1
swissprot - K3W4R2
Ensembl - ENSMUSG00000030739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myh14ENSDARG00000073732Danio rerio
 MYH14ENSG00000105357Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*ENSMUSG0000002090065
Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*ENSMUSG0000002244363
Myh11 / myosin heavy chain 11 / P35749*ENSMUSG0000001883061
Myh7b / A2AQP0 / Myosin-7B / A7E2Y1* / myosin heavy chain 7B*ENSMUSG0000007465238
Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*ENSMUSG0000002090837
Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*ENSMUSG0000004075237
Myh7 / Q91Z83 / Myosin-7 / P12883* / myosin heavy chain 7*ENSMUSG0000005309337
Myh2 / myosin heavy chain 2 / Q9UKX2*ENSMUSG0000003319636
Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*ENSMUSG0000005577536
Myh13 / myosin heavy chain 13 / Q9UKX3*ENSMUSG0000006018035
Myh4 / Q5SX39 / Myosin-4 / Q9Y623* / myosin heavy chain 4*ENSMUSG0000005700335
Myh1 / Q5SX40 / Myosin-1 / P12882* / myosin heavy chain 1*ENSMUSG0000005632835
Myh15 / myosin heavy chain 15 / Q9Y2K3*ENSMUSG0000009200933


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003009 skeletal muscle contraction ISO
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007519 skeletal muscle tissue development ISO
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0019228 neuronal action potential ISO
 biological_processGO:0030048 actin filament-based movement IDA
 biological_processGO:0031032 actomyosin structure organization ISO
 biological_processGO:0070584 mitochondrion morphogenesis ISO
 biological_processGO:0071625 vocalization behavior ISO
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016460 myosin II complex ISO
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0042641 actomyosin ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0097513 myosin II filament ISO
 molecular_functionGO:0000146 microfilament motor activity IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0030898 actin-dependent ATPase activity ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Myh14tm2Rsad/Myh14+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000034868 Myl12b / Q3THE2 / Myosin regulatory light chain 12B / O14950* / myosin light chain 12B*  / complex
 ENSMUSG00000030739 Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*  / complex
 ENSMUSG00000020900 Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*  / complex
 ENSMUSG00000022443 Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*  / complex
 ENSMUSG00000018830 Myh11 / myosin heavy chain 11 / P35749*  / complex
 ENSMUSG00000090841 Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*  / complex






 

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