ENSMUSG00000057003


Mus musculus

Features
Gene ID: ENSMUSG00000057003
  
Biological name :Myh4
  
Synonyms : Myh4 / Myosin-4 / Q5SX39
  
Possible biological names infered from orthology : myosin heavy chain 4 / Q9Y623
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 67238029
Gene end: 67260446
  
Corresponding Affymetrix probe sets: 10377117 (MoGene1.0st)   1427026_at (Mouse Genome 430 2.0 Array)   1458368_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018632
Ensembl peptide - ENSMUSP00000127514
NCBI entrez gene - 17884     See in Manteia.
MGI - MGI:1339713
RefSeq - NM_010855
RefSeq Peptide - NP_034985
swissprot - Q5SX39
Ensembl - ENSMUSG00000057003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079179.1ENSDARG00000110596Danio rerio
 myhbENSDARG00000001993Danio rerio
 myhz1.1ENSDARG00000102414Danio rerio
 myhz1.3ENSDARG00000067997Danio rerio
 myhz2ENSDARG00000012944Danio rerio
 zgc:66156ENSDARG00000112287Danio rerio
 MYH1AENSGALG00000037864Gallus gallus
 MYH1BENSGALG00000039977Gallus gallus
 MYH1CENSGALG00000032404Gallus gallus
 MYH1DENSGALG00000027323Gallus gallus
 MYH1FENSGALG00000042257Gallus gallus
 MYH1GENSGALG00000028612Gallus gallus
 MYH4ENSG00000264424Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myh1 / Q5SX40 / Myosin-1 / P12882* / myosin heavy chain 1*ENSMUSG0000005632895
Myh2 / myosin heavy chain 2 / Q9UKX2*ENSMUSG0000003319693
Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*ENSMUSG0000005577592
Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*ENSMUSG0000002090884
Myh13 / myosin heavy chain 13 / Q9UKX3*ENSMUSG0000006018083
Myh7 / Q91Z83 / Myosin-7 / P12883* / myosin heavy chain 7*ENSMUSG0000005309382
Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*ENSMUSG0000004075281
Myh7b / A2AQP0 / Myosin-7B / A7E2Y1* / myosin heavy chain 7B*ENSMUSG0000007465267
Myh15 / myosin heavy chain 15 / Q9Y2K3*ENSMUSG0000009200956
Myh11 / myosin heavy chain 11 / P35749*ENSMUSG0000001883040
Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*ENSMUSG0000002244340
Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*ENSMUSG0000002090040
Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*ENSMUSG0000003073937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction ISO
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0014823 response to activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0032982 myosin filament IEA
 molecular_functionGO:0000146 microfilament motor activity TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding ISO
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srctm1Mul/Srctm1Mul,Tg(MMTV-cre)7Mul/0,Tg(MMTV-PyVT)#Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Srctm1Mul/Srctm1Mul,Tg(MMTV-cre)7Mul/0,Tg(MMTV-PyVT)#Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srctm1Mul/Srctm1Mul,Tg(MMTV-cre)7Mul/0,Tg(MMTV-PyVT)#Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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