ENSMUSG00000040752


Mus musculus

Features
Gene ID: ENSMUSG00000040752
  
Biological name :Myh6
  
Synonyms : Myh6 / myosin, heavy polypeptide 6, cardiac muscle, alpha / Q02566
  
Possible biological names infered from orthology : myosin heavy chain 6 / P13533
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 54941921
Gene end: 54966927
  
Corresponding Affymetrix probe sets: 10419900 (MoGene1.0st)   1417729_at (Mouse Genome 430 2.0 Array)   1448554_s_at (Mouse Genome 430 2.0 Array)   1448826_at (Mouse Genome 430 2.0 Array)   1448827_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153961
Ensembl peptide - ENSMUSP00000154634
Ensembl peptide - ENSMUSP00000080538
Ensembl peptide - ENSMUSP00000107083
Ensembl peptide - ENSMUSP00000115615
NCBI entrez gene - 17888     See in Manteia.
MGI - MGI:97255
RefSeq - XM_006518678
RefSeq - XM_006518677
RefSeq - NM_001164171
RefSeq - NM_010856
RefSeq Peptide - NP_034986
RefSeq Peptide - NP_001157643
swissprot - Q02566
swissprot - Q1WNP4
swissprot - B8JJH3
swissprot - B2RQQ1
Ensembl - ENSMUSG00000040752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU633479.1ENSDARG00000098747Danio rerio
 CU633479.2ENSDARG00000103837Danio rerio
 myh6ENSDARG00000090637Danio rerio
 myh7ENSDARG00000079564Danio rerio
 myh7lENSDARG00000079782Danio rerio
 smyhc1ENSDARG00000099959Danio rerio
 smyhc2ENSDARG00000103969Danio rerio
 smyhc2ENSDARG00000114031Danio rerio
 MYH7ENSGALG00000035594Gallus gallus
 MYH6ENSG00000197616Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myh7 / Q91Z83 / Myosin-7 / P12883* / myosin heavy chain 7*ENSMUSG0000005309393
Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*ENSMUSG0000005577581
Myh4 / Q5SX39 / Myosin-4 / Q9Y623* / myosin heavy chain 4*ENSMUSG0000005700381
Myh1 / Q5SX40 / Myosin-1 / P12882* / myosin heavy chain 1*ENSMUSG0000005632881
Myh2 / myosin heavy chain 2 / Q9UKX2*ENSMUSG0000003319681
Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*ENSMUSG0000002090879
Myh13 / myosin heavy chain 13 / Q9UKX3*ENSMUSG0000006018078
Myh7b / A2AQP0 / Myosin-7B / A7E2Y1* / myosin heavy chain 7B*ENSMUSG0000007465269
Myh15 / myosin heavy chain 15 / Q9Y2K3*ENSMUSG0000009200957
Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*ENSMUSG0000002090040
Myh11 / myosin heavy chain 11 / P35749*ENSMUSG0000001883040
Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*ENSMUSG0000002244340
Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*ENSMUSG0000003073938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002026 regulation of the force of heart contraction ISO
 biological_processGO:0002027 regulation of heart rate ISO
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0007522 visceral muscle development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:0030048 actin filament-based movement IMP
 biological_processGO:0030049 muscle filament sliding ISO
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0043462 regulation of ATPase activity IMP
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0048739 cardiac muscle fiber development IMP
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis ISO
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis ISO
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060420 regulation of heart growth IDA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030016 myofibril IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0032982 myosin filament IEA
 molecular_functionGO:0000146 microfilament motor activity ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030898 actin-dependent ATPase activity ISO
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm2Jse/Myh6+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf5tm2Tajb/Myf5tm2Tajb,Myf6tm1Tajb/Myf6+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Myh6tm3.1Jse/Myh6+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Myh6tm1Jse/Myh6+,Postntm1Jmol/Postntm1Jmol
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm3.1Jse/Myh6+
Genetic Background: involves: 129X1/SvJ

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm1Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm1Ces/Myh6tm1Ces
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm2Ces/Myh6tm2Ces
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm2Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm1Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm1Ces/Myh6tm1Ces
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm2Ces/Myh6tm2Ces
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm2Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm3.1Jse/Myh6+
Genetic Background: involves: 129X1/SvJ

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myh6tm2Jse/Myh6+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

Allelic Composition: Myh6tm3.1Jse/Myh6+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Myh6tm1Jse/Myh6+,Postntm1Jmol/Postntm1Jmol
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003821 decreased left ventricle diastolic pressure "decrease in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0004070 abnormal P wave "any anomaly in the P wave which is normally caused by atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions; irregular or absent P waves may indicate arrhythmia and the shape of the P waves may indicate atrial problems" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm2Jse/Myh6+
Genetic Background: involves: 129S1/Sv

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myh6tm1Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm1Ces/Myh6tm1Ces
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm2Ces/Myh6tm2Ces
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm2Ces/Myh6+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Myh6tm3.1Jse/Myh6+
Genetic Background: involves: 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm2Jse/Myh6+
Genetic Background: involves: 129S1/Sv

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myh6tm1Jse/Myh6+
Genetic Background: 129S.129X1-Myh6tm1Jse

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008775 abnormal heart ventricular pressure "any anomaly in the pressure within a cardiac ventricle" [MESH:G09.330.553.660.937]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm3.1Jse/Myh6+
Genetic Background: involves: 129X1/SvJ

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Postntm1Jmol/Postntm1Jmol
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010506 prolonged RR interval "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0010630 abnormal cardiac muscle tissue morphology "any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Myh6tm1Jse/Myh6tm1Jse
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Timp1tm1Pds/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Myh6tm1Jse/Myh6+,Tg(Myh6-TNNI3*G203S)1Chs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020908 Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*  / complex / reaction
 ENSMUSG00000051747 Ttn / titin / A2ASS6 / Q8WZ42*  / complex / reaction
 ENSMUSG00000055775 Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*  / complex / reaction
 ENSMUSG00000038670 Mybpc2 / Q5XKE0 / Myosin-binding protein C, fast-type / Q14324*  / reaction / complex
 ENSMUSG00000061816 Myl1 / P05977 / Myosin light chain 1/3, skeletal muscle isoform / P05976* / myosin light chain 1*  / complex / reaction
 ENSMUSG00000002100 Mybpc3 / myosin binding protein C, cardiac / Q14896*  / reaction / complex
 ENSMUSG00000020061 Mybpc1 / myosin binding protein C, slow type / Q00872*  / reaction / complex
 ENSMUSG00000040752 Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*  / reaction / complex
 ENSMUSG00000061086 Myl4 / Mus musculus myosin, light polypeptide 4 (Myl4), transcript variant 2, mRNA. / P12829* / myosin light chain 4*  / complex / reaction
 ENSMUSG00000059741 Myl3 / P09542 / Myosin light chain 3 / P08590*  / complex / reaction
 ENSMUSG00000013936 Myl2 / P51667 / Myosin regulatory light chain 2, ventricular/cardiac muscle isoform / P10916* / myosin light chain 2*  / reaction / complex






 

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