ENSMUSG00000061816


Mus musculus

Features
Gene ID: ENSMUSG00000061816
  
Biological name :Myl1
  
Synonyms : Myl1 / Myosin light chain 1/3, skeletal muscle isoform / P05977
  
Possible biological names infered from orthology : myosin light chain 1 / P05976
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 66924295
Gene end: 66945404
  
Corresponding Affymetrix probe sets: 10355259 (MoGene1.0st)   1452651_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112880
Ensembl peptide - ENSMUSP00000140834
Ensembl peptide - ENSMUSP00000125748
Ensembl peptide - ENSMUSP00000027151
Ensembl peptide - ENSMUSP00000112861
NCBI entrez gene - 17901     See in Manteia.
MGI - MGI:97269
RefSeq - NM_021285
RefSeq - XM_011238451
RefSeq - XM_006495763
RefSeq - NM_001113387
RefSeq Peptide - NP_067260
RefSeq Peptide - NP_001106858
swissprot - E9PWG4
swissprot - P05977
swissprot - Q545G5
swissprot - Q545T7
swissprot - A0A087WRZ7
swissprot - E0CZ30
Ensembl - ENSMUSG00000061816
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myl1ENSDARG00000014196Danio rerio
 mylz3ENSDARG00000017441Danio rerio
 MYL1ENSGALG00000002907Gallus gallus
 MYL1ENSG00000168530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myl3 / P09542 / Myosin light chain 3 / P08590*ENSMUSG0000005974174
Myl4 / Mus musculus myosin, light polypeptide 4 (Myl4), transcript variant 2, mRNA. / P12829* / myosin light chain 4*ENSMUSG0000006108670
Myl6b / Q8CI43 / Myosin light chain 6B / P14649*ENSMUSG0000003982469
Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*ENSMUSG0000009084155


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction ISO
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030016 myofibril ISO
 cellular_componentGO:0043292 contractile fiber IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Isl1tm1(cre)Tmj/Isl1+,Shc1tm9Paw/Shc1tm9.1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm4Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm7Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm9Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm3Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm7Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm9Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm3Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm4Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm7Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm4Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm9Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm3Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Shc1tm7Paw/Shc1tm9Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0011201 abnormal visceral yolk sac cavity morphology "any structural anomaly of the closed space containing the yolk, formed by the fusion of the edges of the embryonic epiblast (hypoblast) and later surrounded by the visceral yolk sac (hypoblast and visceral yolk sac mesoderm)" [ISBN:0-12-402035-6, PMID:21123814]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020908 Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*  / complex / reaction
 ENSMUSG00000051747 Ttn / titin / A2ASS6 / Q8WZ42*  / complex
 ENSMUSG00000055775 Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*  / reaction / complex
 ENSMUSG00000013936 Myl2 / P51667 / Myosin regulatory light chain 2, ventricular/cardiac muscle isoform / P10916* / myosin light chain 2*  / complex
 ENSMUSG00000002100 Mybpc3 / myosin binding protein C, cardiac / Q14896*  / complex
 ENSMUSG00000061816 Myl1 / P05977 / Myosin light chain 1/3, skeletal muscle isoform / P05976* / myosin light chain 1*  / complex
 ENSMUSG00000061086 Myl4 / Mus musculus myosin, light polypeptide 4 (Myl4), transcript variant 2, mRNA. / P12829* / myosin light chain 4*  / complex
 ENSMUSG00000020061 Mybpc1 / myosin binding protein C, slow type / Q00872*  / complex
 ENSMUSG00000059741 Myl3 / P09542 / Myosin light chain 3 / P08590*  / complex
 ENSMUSG00000038670 Mybpc2 / Q5XKE0 / Myosin-binding protein C, fast-type / Q14324*  / complex
 ENSMUSG00000040752 Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*  / complex / reaction






 

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