ENSMUSG00000061086


Mus musculus

Features
Gene ID: ENSMUSG00000061086
  
Biological name :Myl4
  
Synonyms : Mus musculus myosin, light polypeptide 4 (Myl4), transcript variant 2, mRNA. / Myl4
  
Possible biological names infered from orthology : myosin light chain 4 / P12829
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 104550663
Gene end: 104595753
  
Corresponding Affymetrix probe sets: 10381798 (MoGene1.0st)   1422580_at (Mouse Genome 430 2.0 Array)   1457126_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018800
Ensembl peptide - ENSMUSP00000114345
Ensembl peptide - ENSMUSP00000122748
Ensembl peptide - ENSMUSP00000118284
Ensembl peptide - ENSMUSP00000102569
Ensembl peptide - ENSMUSP00000102570
NCBI entrez gene - 17896     See in Manteia.
MGI - MGI:97267
RefSeq - XM_006532417
RefSeq - XM_011248789
RefSeq - XM_006532418
RefSeq - NM_001355754
RefSeq - NM_001355755
RefSeq - NM_010858
RefSeq Peptide - NP_001342683
RefSeq Peptide - NP_001342684
RefSeq Peptide - NP_034988
swissprot - Q9CZ19
swissprot - D6RFU4
swissprot - A2A6Q8
swissprot - F6XL79
Ensembl - ENSMUSG00000061086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cmlc1ENSDARG00000032976Danio rerio
 myl4ENSDARG00000011519Danio rerio
 MYL4ENSGALG00000000585Gallus gallus
 MYL4ENSG00000198336Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myl3 / P09542 / Myosin light chain 3 / P08590*ENSMUSG0000005974177
Myl1 / P05977 / Myosin light chain 1/3, skeletal muscle isoform / P05976* / myosin light chain 1*ENSMUSG0000006181668
Myl6b / Q8CI43 / Myosin light chain 6B / P14649*ENSMUSG0000003982463
Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*ENSMUSG0000009084155


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0031672 A band IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Mybpc3tm1a(EUCOMM)Hmgu/Mybpc3tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm1a(EUCOMM)Hmgu/Mybpc3tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm1a(EUCOMM)Hmgu/Mybpc3tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020908 Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*  / reaction / complex
 ENSMUSG00000051747 Ttn / titin / A2ASS6 / Q8WZ42*  / complex
 ENSMUSG00000038670 Mybpc2 / Q5XKE0 / Myosin-binding protein C, fast-type / Q14324*  / complex
 ENSMUSG00000020061 Mybpc1 / myosin binding protein C, slow type / Q00872*  / complex
 ENSMUSG00000013936 Myl2 / P51667 / Myosin regulatory light chain 2, ventricular/cardiac muscle isoform / P10916* / myosin light chain 2*  / complex
 ENSMUSG00000061086 Myl4 / Mus musculus myosin, light polypeptide 4 (Myl4), transcript variant 2, mRNA. / P12829* / myosin light chain 4*  / complex
 ENSMUSG00000002100 Mybpc3 / myosin binding protein C, cardiac / Q14896*  / complex
 ENSMUSG00000055775 Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*  / complex / reaction
 ENSMUSG00000061816 Myl1 / P05977 / Myosin light chain 1/3, skeletal muscle isoform / P05976* / myosin light chain 1*  / complex
 ENSMUSG00000040752 Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*  / complex / reaction
 ENSMUSG00000059741 Myl3 / P09542 / Myosin light chain 3 / P08590*  / complex






 

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