ENSDARG00000009782


Danio rerio

Features
Gene ID: ENSDARG00000009782
  
Biological name :myh11a
  
Synonyms : myh11a / myosin, heavy chain 11a, smooth muscle
  
Possible biological names infered from orthology : MYH11 / myosin heavy chain 11 / P35749
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 8499865
Gene end: 8580858
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000041141
Ensembl peptide - ENSDARP00000121781
NCBI entrez gene - 554168     See in Manteia.
RefSeq - NM_001024448
RefSeq Peptide - NP_001019619
swissprot - E9QEW5
swissprot - B3DFS9
ZFIN ID - ZDB-GENE-050531-1
Ensembl - ENSDARG00000009782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYH11ENSGALG00000006520Gallus gallus
 MYH11ENSG00000133392Homo sapiens
 Myh11ENSMUSG00000018830Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
myh11b / myosin, heavy chain 11b, smooth muscle / MYH11* / P35749* / myosin heavy chain 11*ENSDARG0000010097274
myh10 / myosin, heavy chain 10, non-muscle / Q61879* / P35580* / Myosin-10 * / myosin heavy chain 10*ENSDARG0000000010372
myh9a / myosin, heavy chain 9a, non-muscle / MYH9* / P35579* / Q8VDD5* / myosin heavy chain 9* / myosin, heavy polypeptide 9, non-muscle*ENSDARG0000006329569
myh9b / myosin, heavy chain 9b, non-muscle / MYH9* / P35579* / Q8VDD5* / myosin heavy chain 9* / myosin, heavy polypeptide 9, non-muscle*ENSDARG0000000101463
myh14 / myosin, heavy chain 14, non-muscle / Q7Z406* / Q6URW6* / Myosin-14 * / myosin heavy chain 14*ENSDARG0000007373260
smyhc2 / slow myosin heavy chain 2 / MYH7* / MYH6* / P12883* / P13533* / myosin heavy chain 7* / myosin heavy chain 6*ENSDARG0000010396940
CU633479.2 / MYH6* / MYH7* / P13533* / P12883* / myosin heavy chain 6* / myosin heavy chain 7*ENSDARG0000010383740
myh7 / myosin heavy chain 7 / MYH6* / Q91Z83* / P12883* / P13533* / Q02566* / Myosin-7 * / myosin heavy chain 6* / myosin, heavy polypeptide 6, cardiac muscle, alpha*ENSDARG0000007956440
myh7l / myosin heavy chain 7-like / MYH6* / MYH7* / Q91Z83* / P12883* / P13533* / Q02566* / Myosin-7 * / myosin heavy chain 7* / myosin heavy chain 6* / myosin, heavy polypeptide 6, cardiac...ENSDARG0000007978240
myhz1.3 / myosin, heavy polypeptide 1.3, skeletal muscle / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / P13542* / Q5SX39* / Q5SX40* / Q9UKX2* / Q9UKX3* / Myosin-1 ...ENSDARG0000006799739
smyhc2 / slow myosin heavy chain 2 / MYH7* / MYH6* / P12883* / P13533* / myosin heavy chain 7* / myosin heavy chain 6*ENSDARG0000011403139
smyhc1 / slow myosin heavy chain 1 / MYH7* / MYH6* / P12883* / P13533* / myosin heavy chain 7* / myosin heavy chain 6*ENSDARG0000009995939
myhz2 / myosin, heavy polypeptide 2, fast muscle specific / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / P13542* / Q5SX39* / Q5SX40* / Q9UKX2* / Q9UKX3* / Myosin-1...ENSDARG0000001294439
myh7ba / myosin, heavy chain 7B, cardiac muscle, beta a / MYH7B* / A7E2Y1* / A2AQP0* / Myosin-7B * / myosin heavy chain 7B*ENSDARG0000007607539
myhb / myosin, heavy chain b / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / P13542* / Q5SX39* / Q5SX40* / Q9UKX2* / Q9UKX3* / Myosin-1 * / Myosin-8 * / Myosin-4 * ...ENSDARG0000000199339
myh7bb / myosin, heavy chain 7B, cardiac muscle, beta b / MYH7B* / A7E2Y1* / A2AQP0* / Myosin-7B * / myosin heavy chain 7B*ENSDARG0000003532239
myh6 / myosin, heavy chain 6, cardiac muscle, alpha / MYH7* / Q91Z83* / P12883* / P13533* / Q02566* / Myosin-7 * / myosin heavy chain 6* / myosin heavy chain 7* / myosin, heavy polypeptide ...ENSDARG0000009063738
CU633479.1 / MYH6* / MYH7* / P13533* / P12883* / myosin heavy chain 6* / myosin heavy chain 7*ENSDARG0000009874731
myhz1.1 / myosin, heavy polypeptide 1.1, skeletal muscle / MYH2* / MYH4* / MYH8* / MYH1* / MYH13* / Q9Y623* / P12882* / P13535* / Q9UKX2* / Q9UKX3* / myosin heavy chain 1* / myosin heavy ch...ENSDARG0000010241431
zgc:66156 / MYH1* / MYH2* / MYH4* / MYH8* / MYH13* / P13535* / Q9UKX2* / Q9UKX3* / Q9Y623* / P12882* / myosin heavy chain 1* / myosin heavy chain 2* / myosin heavy chain 4* / myosin heavy c...ENSDARG0000011228714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0030860 regulation of polarized epithelial cell differentiation IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 cellular_componentGO:0016459 myosin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000005 artery artery decreased diameter , abnormal
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 ZFA:0000112 gut gut quality , abnormal
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 ZFA:0000706 posterior intestine posterior intestine epithelial cell migration increased occurrence , abnormal
posterior intestine distended , abnormal
posterior intestine cystic , abnormal
posterior intestine undulate , abnormal
posterior intestine mesenchymal cell morphology , abnormal
posterior intestine mesenchymal cell increased amount , abnormal
posterior intestine mesenchymal cell degenerate , abnormal
posterior intestine smooth muscle cell irregular spatial pattern , abnormal
posterior intestine mesenchyme distended , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001323 mid intestine mid intestine epithelial cell migration increased occurrence , abnormal
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 ZFA:0001338 intestine intestine morphology , abnormal
intestine enteric musculature morphology , abnormal
intestine smooth muscle non-contractile , abnormal
intestine basement membrane discontinuous , abnormal
intestine cystic , abnormal
intestine lumenized , ameliorated
intestine peristalsis decreased efficacy , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0005124 intestinal epithelium intestinal epithelium cytoskeletal part mislocalised , abnormal
intestinal epithelium invadopodium present , abnormal
intestinal epithelium basal lamina degenerate , abnormal
intestinal epithelium cystic , abnormal
intestinal epithelium stratified , abnormal
intestinal epithelium focal adhesion degenerate , abnormal
intestinal epithelium basal lamina damaged , abnormal
intestinal epithelium basement membrane spatial pattern , abnormal
intestinal epithelium hypertrophic , abnormal
intestinal epithelium invadopodium increased amount , abnormal
intestinal epithelium mislocalised , abnormal
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 ZFA:0005128 posterior intestine epithelium posterior intestine epithelium morphology , abnormal
posterior intestine epithelium stratification , abnormal
posterior intestine epithelium basement membrane morphology , abnormal
posterior intestine epithelium disorganized , abnormal
posterior intestine epithelium cystic , abnormal
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 ZFA:0005274 smooth muscle smooth muscle myosin complex morphology , abnormal
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 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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