ENSGALG00000031495


Gallus gallus

Features
Gene ID: ENSGALG00000031495
  
Biological name :TRIO
  
Synonyms : TRIO / trio Rho guanine nucleotide exchange factor
  
Possible biological names infered from orthology : O75962 / Q0KL02 / Triple functional domain protein
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 76545808
Gene end: 76794884
  
Corresponding Affymetrix probe sets: Gga.10387.1.S1_s_at (Chicken Array)   Gga.13584.1.S1_at (Chicken Array)   Gga.16040.1.S1_at (Chicken Array)   Gga.17901.1.S1_at (Chicken Array)   Gga.17901.1.S1_s_at (Chicken Array)   GgaAffx.24078.1.S1_s_at (Chicken Array)   GgaAffx.24078.3.S1_s_at (Chicken Array)   GgaAffx.24078.4.S1_s_at (Chicken Array)   GgaAffx.24078.5.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045938
NCBI entrez gene - 420919     See in Manteia.
RefSeq - XM_015282226
swissprot - A0A1D5NZW8
Ensembl - ENSGALG00000031495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trioaENSDARG00000019426Danio rerio
 triobENSDARG00000000370Danio rerio
 TRIOENSG00000038382Homo sapiens
 TrioENSMUSG00000022263Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KALRN / kalirin RhoGEF kinase / A2CG49* / O60229* / Kalirin *ENSGALG0000001174463
MCF2L2 / MCF.2 cell line derived transforming sequence-like 2 / Q86YR7*ENSGALG0000000874410
MCF2L / MCF.2 cell line derived transforming sequence like / O15068*ENSGALG0000001683410
MCF2 / MCF.2 cell line derived transforming sequence / P10911*ENSGALG000000065629
PLEKHG1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSGALG000000123955
A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSGALG000000374093
A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSGALG000000361993


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000719  Protein kinase domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018159  Spectrin/alpha-actinin
 IPR028570  Triple functional domain protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (q) signalling events
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015176 GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSGALG00000015177 GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex






 

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