Manteia - Molecule gene

ENSMUSG00000017781

Mus musculus

Features

Gene ID:	ENSMUSG00000017781

Biological name :	Pitpna

Synonyms :	P53810 / phosphatidylinositol transfer protein, alpha / Pitpna

Possible biological names infered from orthology :	Q00169

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	B5
Gene start:	75588097
Gene end:	75628804

Corresponding Affymetrix probe sets:	10378668 (MoGene1.0st) 1423282_at (Mouse Genome 430 2.0 Array) 1423283_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000099567 Ensembl peptide - ENSMUSP00000137510 Ensembl peptide - ENSMUSP00000115723 Ensembl peptide - ENSMUSP00000137601 NCBI entrez gene - 18738 See in Manteia. MGI - MGI:99887 RefSeq - NM_008850 RefSeq Peptide - NP_032876 swissprot - Q5ND42 swissprot - F8WGG5 swissprot - J3QPW1 swissprot - J3QQ30 swissprot - P53810 Ensembl - ENSMUSG00000017781

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pitpnaa	ENSDARG00000039490	Danio rerio
pitpnab	ENSDARG00000044091	Danio rerio
	ENSGALG00000035005	Gallus gallus
	ENSGALG00000023806	Gallus gallus
PITPNA	ENSG00000174238	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P53811 / Pitpnb / phosphatidylinositol transfer protein, beta / P48739*	ENSMUSG00000050017	77
O35954 / Pitpnm1 / Membrane-associated phosphatidylinositol transfer protein 1 / O00562* / phosphatidylinositol transfer protein membrane associated 1*	ENSMUSG00000024851	46
Q6ZPQ6 / Pitpnm2 / Membrane-associated phosphatidylinositol transfer protein 2 / Q9BZ72* / phosphatidylinositol transfer protein membrane associated 2*	ENSMUSG00000029406	45
Q8K4R4 / Pitpnc1 / Cytoplasmic phosphatidylinositol transfer protein 1 / Q9UKF7* / phosphatidylinositol transfer protein, cytoplasmic 1*	ENSMUSG00000040430	42
Q3UHE1 / Pitpnm3 / Membrane-associated phosphatidylinositol transfer protein 3 / Q9BZ71* / PITPNM family member 3*	ENSMUSG00000040543	3

Protein motifs (from Interpro)

Interpro ID	Name
IPR001666	Phosphatidylinositol transfer protein
IPR023393	START-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007409	axonogenesis	IMP
biological_process	GO:0015914	phospholipid transport	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0016021	integral component of membrane	ISS
cellular_component	GO:0043209	myelin sheath	IDA
molecular_function	GO:0005543	phospholipid binding	ISO
molecular_function	GO:0005548	phospholipid transporter activity	IEA
molecular_function	GO:0008289	lipid binding	ISS
molecular_function	GO:0008525	phosphatidylcholine transporter activity	IEA
molecular_function	GO:0008526	phosphatidylinositol transporter activity	IEA
molecular_function	GO:0031210	phosphatidylcholine binding	IEA
molecular_function	GO:0035091	phosphatidylinositol binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000010	abnormal abdominal fat pads	"malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]	Show Allelic Composition: Ush1c^dfcr/Ush1c^dfcr Genetic Background: involves: BALB/cByJ Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000479	abnormal intestinal cell	"anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000488	abnormal intestinal epithelium morphology	"anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ush1c^dfcr/Ush1c^dfcr Genetic Background: involves: BALB/cByJ Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nos2^tm1Mrl/Nos2^tm1Mrl Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Nxf1^Mvb1/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C3HeB/Fe * C57BL/6J * CAST/Ei * DBA/2J Allelic Composition: Nxf1^em1Haml/Nxf1⁺,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J Allelic Composition: Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nos2^tm1Mrl/Nos2^tm1Mrl Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ush1c^dfcr/Ush1c^dfcr Genetic Background: involves: BALB/cByJ Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tek^{tm1.1(icre/Esr1)Hrr}/Tek^{tm1.1(icre/Esr1)Hrr} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Ush1c^dfcr/Ush1c^dfcr Genetic Background: involves: BALB/cByJ Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001671	abnormal vitamin absorption	"anomalous ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001745	increased circulating corticosterone level	"greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ush1c^dfcr/Ush1c^dfcr Genetic Background: involves: BALB/cByJ Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nos2^tm1Mrl/Nos2^tm1Mrl Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nxf1^Mvb1/Nxf1⁺,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * CAST/Ei * DBA/2J
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002696	decreased circulating glucagon level	"lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002715	reduced glycogen catabolism rate	"decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Nos2^tm1Mrl/Nos2^tm1Mrl Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Nxf1^Mvb1/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * CAST/Ei * DBA/2J Allelic Composition: Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J
MP:0002883	chromatolysis	"the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Nos2^tm1Mrl/Nos2^tm1Mrl Genetic Background: involves: 129S7/SvEvBrd
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0003224	neuron degeneration	"a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nos2^tm1Mrl/Nos2^tm1Mrl Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^vb/Pitpna^vb Genetic Background: involves: C3HeB/Fe * C57BL/6J * DBA/2J Allelic Composition: Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J
MP:0005112	abnormal anterior horn morphology	"anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005336	abnormal inguinal fat pad	"malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005342	abnormal lipid absorption	"anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0008027	abnormal spinal cord white matter morphology	"any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0009168	decreased pancreatic islet number	"reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0010769	abnormal survival	"deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nxf1^em1Haml/Nxf1⁺,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Pitpna^tm1Vab/Pitpna^tm1Vab Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0011231	abnormal vitamin E level	"any anomaly in the concentration of vitamin E, tocopherol, including a series of eight structurally similar compounds; alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant" [GO:0010189]	Show Allelic Composition: Pitpna^{Gt(OST1152)Lex}/Pitpna^{Gt(OST1152)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6J * DBA/2J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000060534	Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*	/ reaction / complex
ENSMUSG00000020902	Ntn1 / O09118 / Netrin-1 / O95631*	/ reaction / complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr