ENSG00000174238


Homo sapiens

Features
Gene ID: ENSG00000174238
  
Biological name :PITPNA
  
Synonyms : phosphatidylinositol transfer protein alpha / PITPNA / Q00169
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.3
Gene start: 1517718
Gene end: 1562816
  
Corresponding Affymetrix probe sets: 201190_s_at (Human Genome U133 Plus 2.0 Array)   201191_at (Human Genome U133 Plus 2.0 Array)   201192_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461801
Ensembl peptide - ENSP00000461245
Ensembl peptide - ENSP00000461539
Ensembl peptide - ENSP00000316809
Ensembl peptide - ENSP00000441869
Ensembl peptide - ENSP00000460008
Ensembl peptide - ENSP00000460771
Ensembl peptide - ENSP00000460983
Ensembl peptide - ENSP00000461011
Ensembl peptide - ENSP00000461140
NCBI entrez gene - 5306     See in Manteia.
OMIM - 600174
RefSeq - XM_011523940
RefSeq - NM_006224
RefSeq - XM_011523939
RefSeq Peptide - NP_006215
swissprot - I3L471
swissprot - I3L4C0
swissprot - I3L4H1
swissprot - I3L4U7
swissprot - I3NI10
swissprot - F5GWE5
swissprot - Q00169
swissprot - V9HWC5
swissprot - I3L2X8
swissprot - I3L459
swissprot - I3L3W1
Ensembl - ENSG00000174238
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pitpnaaENSDARG00000039490Danio rerio
 pitpnabENSDARG00000044091Danio rerio
 ENSGALG00000035005Gallus gallus
 ENSGALG00000023806Gallus gallus
 P53810ENSMUSG00000017781Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48739 / PITPNB / phosphatidylinositol transfer protein betaENSG0000018095776
O00562 / PITPNM1 / phosphatidylinositol transfer protein membrane associated 1ENSG0000011069746
Q9BZ72 / PITPNM2 / phosphatidylinositol transfer protein membrane associated 2ENSG0000009097544
Q9UKF7 / PITPNC1 / phosphatidylinositol transfer protein, cytoplasmic 1ENSG0000015421743
Q9BZ71 / PITPNM3 / PITPNM family member 3ENSG000000916222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001666  Phosphatidylinositol transfer protein
 IPR023393  START-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process NAS
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0015914 phospholipid transport IEA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005548 phospholipid transporter activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008525 phosphatidylcholine transporter activity TAS
 molecular_functionGO:0008526 phosphatidylinositol transporter activity TAS
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA
 molecular_functionGO:1901611 phosphatidylglycerol binding TAS


Pathways (from Reactome)
Pathway description
Role of second messengers in netrin-1 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction / complex






 

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