ENSMUSG00000024851


Mus musculus

Features
Gene ID: ENSMUSG00000024851
  
Biological name :Pitpnm1
  
Synonyms : Membrane-associated phosphatidylinositol transfer protein 1 / O35954 / Pitpnm1
  
Possible biological names infered from orthology : O00562 / phosphatidylinositol transfer protein membrane associated 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 4099998
Gene end: 4113965
  
Corresponding Affymetrix probe sets: 10460317 (MoGene1.0st)   1425760_a_at (Mouse Genome 430 2.0 Array)   1437724_x_at (Mouse Genome 430 2.0 Array)   1438854_x_at (Mouse Genome 430 2.0 Array)   1438974_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120563
Ensembl peptide - ENSMUSP00000054309
Ensembl peptide - ENSMUSP00000097599
NCBI entrez gene - 18739     See in Manteia.
MGI - MGI:1197524
RefSeq - NM_008851
RefSeq - XM_006531680
RefSeq - XM_017318081
RefSeq Peptide - NP_032877
swissprot - D3YXW5
swissprot - O35954
Ensembl - ENSMUSG00000024851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PITPNM1ENSGALG00000034939Gallus gallus
 O00562ENSG00000110697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZPQ6 / Pitpnm2 / Membrane-associated phosphatidylinositol transfer protein 2 / Q9BZ72* / phosphatidylinositol transfer protein membrane associated 2*ENSMUSG0000002940657
Q3UHE1 / Pitpnm3 / Membrane-associated phosphatidylinositol transfer protein 3 / Q9BZ71* / PITPNM family member 3*ENSMUSG0000004054337
P53810 / Pitpna / phosphatidylinositol transfer protein, alpha / Q00169*ENSMUSG0000001778110
P53811 / Pitpnb / phosphatidylinositol transfer protein, beta / P48739*ENSMUSG0000005001710
Q8K4R4 / Pitpnc1 / Cytoplasmic phosphatidylinositol transfer protein 1 / Q9UKF7* / phosphatidylinositol transfer protein, cytoplasmic 1*ENSMUSG000000404309


Protein motifs (from Interpro)
Interpro ID Name
 IPR001666  Phosphatidylinositol transfer protein
 IPR004177  DDHD domain
 IPR023214  HAD superfamily
 IPR023393  START-like domain superfamily
 IPR031315  LNS2/PITP
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015914 phospholipid transport ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding ISA
 molecular_functionGO:0005548 phospholipid transporter activity IEA
 molecular_functionGO:0008526 phosphatidylinositol transporter activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PI


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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