ENSMUSG00000040760


Mus musculus

Features
Gene ID: ENSMUSG00000040760
  
Biological name :Appl1
  
Synonyms : Appl1 / DCC-interacting protein 13-alpha / Q8K3H0
  
Possible biological names infered from orthology : adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 / Q9UKG1
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 26918988
Gene end: 26971232
  
Corresponding Affymetrix probe sets: 10418251 (MoGene1.0st)   1427190_at (Mouse Genome 430 2.0 Array)   1436116_x_at (Mouse Genome 430 2.0 Array)   1444478_at (Mouse Genome 430 2.0 Array)   1455159_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042875
NCBI entrez gene - 72993     See in Manteia.
MGI - MGI:1920243
RefSeq - XM_017316214
RefSeq - NM_145221
RefSeq - XM_006519608
RefSeq - XM_006519609
RefSeq Peptide - NP_660256
swissprot - Q8K3H0
Ensembl - ENSMUSG00000040760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 appl1ENSDARG00000060734Danio rerio
 APPL1ENSGALG00000005527Gallus gallus
 APPL1ENSG00000157500Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Appl2 / Q8K3G9 / DCC-interacting protein 13-beta / Q8NEU8* / adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2*ENSMUSG0000002026349


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0046324 regulation of glucose import IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA


Pathways (from Reactome)
Pathway description
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd226tm1Shib/Cd226tm1Shib
Genetic Background: involves: BALB/c

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd226tm1Shib/Cd226tm1Shib
Genetic Background: involves: BALB/c

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdrtm1Jrt/Kdr+,Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Kdrtm1Jrt/Kdr+,Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0020101 abnormal hepatic glucose production "an anomaly in the production of glucose in the liver" [GOC:NV]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / complex / reaction
 ENSMUSG00000028914 Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*  / complex / reaction






 

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