ENSMUSG00000020263


Mus musculus

Features
Gene ID: ENSMUSG00000020263
  
Biological name :Appl2
  
Synonyms : Appl2 / DCC-interacting protein 13-beta / Q8K3G9
  
Possible biological names infered from orthology : adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 / Q8NEU8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 83600033
Gene end: 83648738
  
Corresponding Affymetrix probe sets: 10371356 (MoGene1.0st)   1426743_at (Mouse Genome 430 2.0 Array)   1447426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135645
Ensembl peptide - ENSMUSP00000135157
Ensembl peptide - ENSMUSP00000135672
Ensembl peptide - ENSMUSP00000020500
Ensembl peptide - ENSMUSP00000115903
Ensembl peptide - ENSMUSP00000121336
NCBI entrez gene - 216190     See in Manteia.
MGI - MGI:2384914
RefSeq - XM_017313895
RefSeq - NM_145220
RefSeq - XM_006513508
RefSeq - XM_006513509
RefSeq - XM_006513510
RefSeq - XM_006513511
RefSeq - XM_011243404
RefSeq Peptide - NP_660255
swissprot - Q8K3G9
swissprot - H3BJX0
swissprot - H3BL43
swissprot - Q3TVI6
swissprot - D6RFR7
swissprot - D3Z340
swissprot - H3BL67
Ensembl - ENSMUSG00000020263
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 appl2ENSDARG00000078139Danio rerio
 APPL2ENSGALG00000027122Gallus gallus
 APPL2ENSG00000136044Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Appl1 / Q8K3H0 / DCC-interacting protein 13-alpha / Q9UKG1* / adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1*ENSMUSG0000004076052


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr