ENSMUSG00000030890


Mus musculus

Features
Gene ID: ENSMUSG00000030890
  
Biological name :Ilk
  
Synonyms : Ilk / Integrin-linked protein kinase / O55222
  
Possible biological names infered from orthology : integrin linked kinase / Q13418
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 105736592
Gene end: 105742925
  
Corresponding Affymetrix probe sets: 10556005 (MoGene1.0st)   1449942_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123443
Ensembl peptide - ENSMUSP00000147693
Ensembl peptide - ENSMUSP00000147503
Ensembl peptide - ENSMUSP00000147366
Ensembl peptide - ENSMUSP00000130341
Ensembl peptide - ENSMUSP00000033182
Ensembl peptide - ENSMUSP00000116329
NCBI entrez gene - 16202     See in Manteia.
MGI - MGI:1195267
RefSeq - XM_006507390
RefSeq - NM_001161724
RefSeq - NM_010562
RefSeq - XM_006507389
RefSeq Peptide - NP_034692
RefSeq Peptide - NP_001155196
swissprot - D3YZA5
swissprot - A0A1B0GRF6
swissprot - A0A1B0GR42
swissprot - A0A1B0GRW6
swissprot - F6Q5Z1
swissprot - O55222
Ensembl - ENSMUSG00000030890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ilkENSDARG00000056964Danio rerio
 ILKENSGALG00000031642Gallus gallus
 ILKENSG00000166333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5GIG6 / Tnni3k / TNNI3 interacting kinase / Q59H18* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSMUSG0000004008626
Q66L42 / Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q02779*ENSMUSG0000004039021
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272421
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185320
Q60700 / Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q12852* / mitogen-activated protein kinase kinase kinase 12*ENSMUSG0000002305019
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361819
Q80XI6 / Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q16584*ENSMUSG0000000405419
Q9ESL4 / Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9NYL2*ENSMUSG0000000408516
Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*ENSMUSG0000002828415
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG0000007836512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR035692  Integrin-linked protein kinase, pseudokinase domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007160 cell-matrix adhesion IBA
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009967 positive regulation of signal transduction ISO
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010761 fibroblast migration IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IMP
 biological_processGO:0021675 nerve development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0030030 cell projection organization IMP
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0032288 myelin assembly IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IBA
 biological_processGO:0042327 positive regulation of phosphorylation ISO
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0001725 stress fiber IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO


Pathways (from Reactome)
Pathway description
Localization of the PINCH-ILK-PARVIN complex to focal adhesions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Vhltm1Lss/Vhltm1.1Lss,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Sykm1Btlr/Sykm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ilktm5.1Ref/Ilktm5.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm6.1Ref/Ilktm6.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003604 single kidney 
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0004134 abnormal chest morphology "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sykm1Btlr/Sykm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008060 abnormal podocyte slit diaphragm morphology "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sykm1Btlr/Sykm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Ilktm2Star/Ilk+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ilktm7.1Ref/Ilktm7.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sykm1Btlr/Sykm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ilktm3Ref/Ilktm3Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm8.1Ref/Ilktm8.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0011194 abnormal hair follicle physiology "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, MGI:mnk]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0011282 increased podocyte apoptosis "increase in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Ilktm8.1Ref/Ilktm8.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011483 renal glomerular synechia "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011753 decreased podocyte number "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011846 decreased kidney collecting duct number "smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [MGI:anna]
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Allelic Composition: Ilktm8.1Ref/Ilktm8.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011856 abnormal glomerular filtration barrier function "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman s space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011868 podocyte microvillus transformation "aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011869 detached podocyte "detachment or loss of adhesion of podocyte foot processes from the glomerular basement membrane (GBM); as a consequence, denuded GBM areas at peripheral capillary loops can become foci for adhesions to parietal epithelial cells (glomerular synechiae) and crescent formation, and podocytes and podocyte-specific proteins may be found in the urine" [MGI:anna]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction






 

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