ENSDARG00000056964


Danio rerio

Features
Gene ID: ENSDARG00000056964
  
Biological name :ilk
  
Synonyms : ilk / integrin-linked kinase
  
Possible biological names infered from orthology : Integrin-linked protein kinase / O55222 / Q13418
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 24722580
Gene end: 24759616
  
Corresponding Affymetrix probe sets: Dr.2422.2.S1_at (Zebrafish Array)   Dr.9544.1.S1_at (Zebrafish Array)   NM_200571_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000073983
Ensembl peptide - ENSDARP00000153672
NCBI entrez gene - 393543     See in Manteia.
RefSeq - NM_200571
RefSeq Peptide - NP_956865
swissprot - Q6PHD6
ZFIN ID - ZDB-GENE-040426-1435
Ensembl - ENSDARG00000056964
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ILKENSGALG00000031642Gallus gallus
 ILKENSG00000166333Homo sapiens
 IlkENSMUSG00000030890Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnni3k / TNNI3 interacting kinase / Q59H18* / Q5GIG6* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSDARG0000008693326
map3k9 / mitogen-activated protein kinase kinase kinase 9 / P80192* / Q3U1V8*ENSDARG0000001349121
map3k21 / mitogen-activated protein kinase kinase kinase 21 / Q5TCX8* / Q8VDG6*ENSDARG0000007947319
map3k10 / mitogen-activated protein kinase kinase kinase 10 / Q02779* / Q66L42*ENSDARG0000005567219
MAP3K11 / si:cabz01078036.1 / Q16584* / mitogen-activated protein kinase kinase kinase 11*ENSDARG0000009152117
map3k12 / mitogen-activated protein kinase kinase kinase 12 / Q12852* / Q60700* / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA.*ENSDARG0000010365117
MAP3K13 / si:ch211-45c16.2 / O43283* / Q1HKZ5* / mitogen-activated protein kinase kinase kinase 13*ENSDARG0000000949317
zak / sterile alpha motif and leucine zipper containing kinase AZK / Q9ESL4* / Q9NYL2* / MAP3K20* / mitogen-activated protein kinase kinase kinase 20*ENSDARG0000004461516
zak / sterile alpha motif and leucine zipper containing kinase AZK / Q9ESL4* / Q9NYL2* / MAP3K20* / mitogen-activated protein kinase kinase kinase 20*ENSDARG0000000697815
map3k7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*ENSDARG0000002046914
mos / v-mos Moloney murine sarcoma viral oncogene homolog / P00540* / MOS proto-oncogene, serine/threonine kinase*ENSDARG0000006974413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR035692  Integrin-linked protein kinase, pseudokinase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001885 endothelial cell development IMP
 biological_processGO:0003211 cardiac ventricle formation IMP
 biological_processGO:0006468 protein phosphorylation IC
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0016203 muscle attachment IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IBA
 biological_processGO:0035989 tendon development IMP
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0060047 heart contraction IMP
 cellular_componentGO:0001725 stress fiber IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005925 focal adhesion IBA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0042383 sarcolemma IDA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Localization of the PINCH-ILK-PARVIN complex to focal adhesions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle malformed , abnormal
cardiac ventricle decreased contractility , abnormal
cardiac ventricle non-contractile , abnormal
cardiac ventricle contractility , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000099 brain vasculature brain vasculature broken , abnormal
brain vasculature dilated , abnormal
brain vasculature epithelium decreased thickness , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart decreased contractility , abnormal
heart quality , abnormal
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 ZFA:0000154 sinus venosus sinus venosus increased accumulation blood , abnormal
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 ZFA:0000368 integument integument blistered , abnormal
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 ZFA:0000473 trunk musculature trunk musculature skeletal muscle cell retracted , abnormal
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 ZFA:0001056 myotome myotome refractivity , abnormal
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 ZFA:0001094 whole organism whole organism absent , abnormal
whole organism shape , abnormal
whole organism decreased distribution , abnormal
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 ZFA:0001117 post-vent region post-vent region skeletal muscle cell retracted , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature broken , abnormal
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 ZFA:0005145 muscle muscle damaged , abnormal
muscle dystrophic , abnormal
muscle detached from tendon , abnormal
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 ZFA:0005597 median fin median fin broken , abnormal
median fin ruffled , abnormal
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 ZFA:0009065 endothelial cell endothelial cell morphology , abnormal
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 ZFA:0009090 pigment cell pigment cell quality , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell detached from myoseptum , abnormal
skeletal muscle cell actin cytoskeleton retracted , abnormal
skeletal muscle cell sarcolemma retracted , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell detached from myoseptum , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell detached from myoseptum , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell shape , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex / reaction






 

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