ENSDARG00000020469


Danio rerio

Features
Gene ID: ENSDARG00000020469
  
Biological name :map3k7
  
Synonyms : map3k7 / mitogen-activated protein kinase kinase kinase 7
  
Possible biological names infered from orthology : O43318 / Q62073
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 24149794
Gene end: 24183382
  
Corresponding Affymetrix probe sets: Dr.17131.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000127289
Ensembl peptide - ENSDARP00000138323
Ensembl peptide - ENSDARP00000006286
Ensembl peptide - ENSDARP00000107410
Ensembl peptide - ENSDARP00000127189
NCBI entrez gene - 553788     See in Manteia.
swissprot - A0A0R4IVJ5
swissprot - Q5RIS4
swissprot - Q5RIS5
swissprot - U3JAC3
swissprot - U3JAM1
ZFIN ID - ZDB-GENE-041001-135
Ensembl - ENSDARG00000020469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K7ENSGALG00000015596Gallus gallus
 MAP3K7ENSG00000135341Homo sapiens
 Map3k7ENSMUSG00000028284Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map3k10 / mitogen-activated protein kinase kinase kinase 10 / Q02779* / Q66L42*ENSDARG0000005567223
map3k21 / mitogen-activated protein kinase kinase kinase 21 / Q5TCX8* / Q8VDG6*ENSDARG0000007947323
zak / sterile alpha motif and leucine zipper containing kinase AZK / Q9ESL4* / Q9NYL2* / MAP3K20* / mitogen-activated protein kinase kinase kinase 20*ENSDARG0000000697820
MAP3K13 / si:ch211-45c16.2 / O43283* / Q1HKZ5* / mitogen-activated protein kinase kinase kinase 13*ENSDARG0000000949320
map3k12 / mitogen-activated protein kinase kinase kinase 12 / Q12852* / Q60700* / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA.*ENSDARG0000010365119
map3k9 / mitogen-activated protein kinase kinase kinase 9 / P80192* / Q3U1V8*ENSDARG0000001349119
MAP3K11 / si:cabz01078036.1 / Q16584* / mitogen-activated protein kinase kinase kinase 11*ENSDARG0000009152119
zak / sterile alpha motif and leucine zipper containing kinase AZK / Q9ESL4* / Q9NYL2* / MAP3K20* / mitogen-activated protein kinase kinase kinase 20*ENSDARG0000004461517
tnni3k / TNNI3 interacting kinase / Q59H18* / Q5GIG6* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSDARG0000008693316
mos / v-mos Moloney murine sarcoma viral oncogene homolog / P00540* / MOS proto-oncogene, serine/threonine kinase*ENSDARG0000006974413
ilk / integrin-linked kinase / O55222* / Q13418* / Integrin-linked protein kinase *ENSDARG0000005696412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017421  Mitogen-activated protein (MAP) kinase kinase kinase 7
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0048514 blood vessel morphogenesis IGI
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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