ENSMUSG00000031503


Mus musculus

Features
Gene ID: ENSMUSG00000031503
  
Biological name :Col4a2
  
Synonyms : Col4a2 / Collagen alpha-2(IV) chain Canstatin / P08122
  
Possible biological names infered from orthology : collagen type IV alpha 2 chain / P08572
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 11312805
Gene end: 11449287
  
Corresponding Affymetrix probe sets: 10570068 (MoGene1.0st)   1424051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033899
NCBI entrez gene - 12827     See in Manteia.
MGI - MGI:88455
RefSeq - NM_009932
RefSeq Peptide - NP_034062
swissprot - B2RQQ8
swissprot - P08122
Ensembl - ENSMUSG00000031503
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col4a2ENSDARG00000104110Danio rerio
 COL4A2ENSGALG00000016843Gallus gallus
 COL4A2ENSG00000134871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*ENSMUSG0000003127350
Col4a4 / Q9QZR9 / Collagen alpha-4(IV) chain / P53420* / collagen type IV alpha 4 chain*ENSMUSG0000006715849
Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*ENSMUSG0000003150247
Col4a5 / collagen, type IV, alpha 5 / P29400* / collagen type IV alpha 5 chain*ENSMUSG0000003127446
Col4a3 / Q9QZS0 / Collagen alpha-3(IV) chain Tumstatin / Q01955* / collagen type IV alpha 3 chain*ENSMUSG0000007946544
Col22a1 / collagen, type XXII, alpha 1 / Q8NFW1* / collagen type XXII alpha 1 chain*ENSMUSG0000007902231
Q8BLX7 / Col16a1 / Collagen alpha-1(XVI) chain / Q07092* / collagen type XVI alpha 1 chain*ENSMUSG0000004069030
Q0VF58 / Col19a1 / Collagen alpha-1(XIX) chain / Q14993* / collagen type XIX alpha 1 chain*ENSMUSG0000002614122


Protein motifs (from Interpro)
Interpro ID Name
 IPR001442  Collagen IV, non-collagenous
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR016187  C-type lectin fold
 IPR036954  Collagen IV, non-collagenous domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IGI
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005587 collagen type IV trimer IDA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Non-integrin membrane-ECM interactions
NCAM1 interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

Allelic Composition: Col4a2ENU415/Col4a2ENU415
Genetic Background: C3.Cg-Col4a2ENU415

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

 MP:0010259 anterior polar cataracts "a lens opacity, usually disk-shaped, that is limited to an area in the anterior pole of the lens capsular region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Col4a2ENU4003/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4003

Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0010263 total cataracts "a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0010713 corneal-lenticular stalk "persistent central adhesion between the lens and the cornea" [PMID:18653562]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Col4a2ENU415/Col4a2ENU415
Genetic Background: C3.Cg-Col4a2ENU415

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Col4a2ENU415/Col4a2ENU415
Genetic Background: C3.Cg-Col4a2ENU415

Allelic Composition: Col4a2ENU4020/Col4a2ENU4020
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Col4a2ENU415/Col4a2ENU415
Genetic Background: C3.Cg-Col4a2ENU415

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0011962 increased cornea thickness "increased width of the cornea in the center plane" [MGI:csmith]
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Allelic Composition: Col4a1F247/Col4a1+
Genetic Background: C3.Cg-Col4a1F247

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025044 Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*  / reaction / complex
 ENSMUSG00000002900 Lamb1 / P02469 / Laminin subunit beta-1 / P07942*  / complex / reaction
 ENSMUSG00000031503 Col4a2 / P08122 / Collagen alpha-2(IV) chain Canstatin / P08572* / collagen type IV alpha 2 chain*  / -
 ENSMUSG00000031502 Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*  / complex / -
 ENSMUSG00000031273 Col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*  / -
 ENSMUSG00000031274 Col4a5 / collagen, type IV, alpha 5 / P29400* / collagen type IV alpha 5 chain*  / -






 

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