Manteia - Molecule gene

ENSMUSG00000079465

Mus musculus

Features

Gene ID:	ENSMUSG00000079465

Biological name :	Col4a3

Synonyms :	Col4a3 / Collagen alpha-3(IV) chain Tumstatin / Q9QZS0

Possible biological names infered from orthology :	collagen type IV alpha 3 chain / Q01955

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	C5
Gene start:	82586921
Gene end:	82722059

Corresponding Affymetrix probe sets:	10347807 (MoGene1.0st) 1438779_at (Mouse Genome 430 2.0 Array) 1450224_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000137944 Ensembl peptide - ENSMUSP00000109084 Ensembl peptide - ENSMUSP00000119094 NCBI entrez gene - 12828 See in Manteia. MGI - MGI:104688 RefSeq - NM_007734 RefSeq Peptide - NP_031760 swissprot - Q9QZS0 swissprot - F6RIS8 swissprot - M0QWQ2 Ensembl - ENSMUSG00000079465

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
col4a3	ENSDARG00000003395	Danio rerio
COL4A3	ENSGALG00000038612	Gallus gallus
COL4A3	ENSG00000169031	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Col4a5 / collagen, type IV, alpha 5 / P29400* / collagen type IV alpha 5 chain*	ENSMUSG00000031274	56
Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*	ENSMUSG00000031502	52
Col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*	ENSMUSG00000031273	46
Col4a4 / Q9QZR9 / Collagen alpha-4(IV) chain / P53420* / collagen type IV alpha 4 chain*	ENSMUSG00000067158	46
Col4a2 / P08122 / Collagen alpha-2(IV) chain Canstatin / P08572* / collagen type IV alpha 2 chain*	ENSMUSG00000031503	45
Q8BLX7 / Col16a1 / Collagen alpha-1(XVI) chain / Q07092* / collagen type XVI alpha 1 chain*	ENSMUSG00000040690	32
Col22a1 / collagen, type XXII, alpha 1 / Q8NFW1* / collagen type XXII alpha 1 chain*	ENSMUSG00000079022	32
Q0VF58 / Col19a1 / Collagen alpha-1(XIX) chain / Q14993* / collagen type XIX alpha 1 chain*	ENSMUSG00000026141	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR001442	Collagen IV, non-collagenous
IPR008160	Collagen triple helix repeat
IPR016133	Insect cysteine-rich antifreeze protein
IPR016187	C-type lectin fold
IPR036954	Collagen IV, non-collagenous domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IDA
biological_process	GO:0008283	cell proliferation	IEA
biological_process	GO:0016525	negative regulation of angiogenesis	IEA
biological_process	GO:0032836	glomerular basement membrane development	IMP
biological_process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	IGI
biological_process	GO:0072577	endothelial cell apoptotic process	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005581	collagen trimer	IEA
cellular_component	GO:0005587	collagen type IV trimer	IEA
cellular_component	GO:0005604	basement membrane	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0005178	integrin binding	IEA
molecular_function	GO:0005201	extracellular matrix structural constituent	IEA

Pathways (from Reactome)

Pathway description

Collagen degradation

Extracellular matrix organization

Collagen biosynthesis and modifying enzymes

Signaling by PDGF

Assembly of collagen fibrils and other multimeric structures

Integrin cell surface interactions

Anchoring fibril formation

Crosslinking of collagen fibrils

Laminin interactions

Non-integrin membrane-ECM interactions

NCAM1 interactions

Collagen chain trimerization

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000035	abnormal membranous labyrinth	"malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000048	abnormal stria vascularis	"anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129X1/SvJ-Col4a3^tm1Dec
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001319	irregularly shaped pupil	"shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/Bay
MP:0001661	extended life span	"persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c
MP:0002704	tubular nephritis	"inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Mmp9^tm1Tvu/Mmp9^tm1Tvu Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/Bay
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J
MP:0004366	abnormal strial marginal cells	"any structural abnormality in the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0004368	abnormal stria vascularis vasculature	"any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129X1/SvJ-Col4a3^tm1Dec
MP:0004598	abnormal cochlear basement membrane	"any structural abnormality in the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament enseathing the root cell processes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129X1/SvJ-Col4a3^tm1Dec
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129X1/SvJ-Col4a3^tm1Dec
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0004970	kidney atrophy	"wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6
MP:0005161	hematuria	"presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ
MP:0005264	glomerulosclerosis	"hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6
MP:0005326	abnormal podocytes	"anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005528	decreased glomerular filtration rate	"less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ
MP:0005568	increased circulating total protein level	"greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c
MP:0006264	decreased systolic blood pressure	"abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ
MP:0008059	abnormal podocyte foot process morphology	"any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Tg(Nphs1-rtTA3G)8Jhm/0,Tg(tetO-COL4A3/Col4a3)#aJhm/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0008140	podocyte foot process effacement	"thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J
MP:0009644	uremia	"an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ
MP:0011320	abnormal glomerular capillary morphology	"any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011346	renal tubule atrophy	"acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0011348	abnormal renal glomerulus basement membrane morphology	"any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Mmp9^tm1Tvu/Mmp9^tm1Tvu Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Tg(Nphs1-rtTA3G)8Jhm/0,Tg(tetO-COL4A3/Col4a3)#aJhm/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0011349	abnormal renal glomerulus basement membrane thickness	"increased or decreased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: B6.129X1-Col4a3^tm1Dec
MP:0011353	expanded mesangial matrix	"increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011377	renal glomerulus fibrosis	"formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011402	renal cast	"any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec,Sostdc1^tm1Myan/Sostdc1^tm1Myan Genetic Background: involves: 129X1/SvJ
MP:0011409	increased renal glomerulus basement membrane thickness	"increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Mmp9^tm1Tvu/Mmp9^tm1Tvu Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Tg(Nphs1-rtTA3G)8Jhm/0,Tg(tetO-COL4A3/Col4a3)#aJhm/0 Genetic Background:* involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Col4a3^tm1Jhm/Col4a3^tm1Jhm,Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Tg(tetO-COL4A3/Col4a3)#aJhm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011437	glomerulus hemorrhage	"bleeding in the renal glomerulus" [MGI:anna]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129-Col4a3^tm1Dec/J
MP:0011506	glomerular crescent	"formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ
MP:0011534	granular kidney	"a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [MGI:anna]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011868	podocyte microvillus transformation	"aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury" [MGI:anna]	Show Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Gli3^Xt-J/Gli3^Xt-J Genetic Background: involves: C3H/HeJ Allelic Composition: Col4a3^tm1Dec/Col4a3^tm1Dec Genetic Background: 129X1/SvJ-Col4a3^tm1Dec

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000067158	Col4a4 / Q9QZR9 / Collagen alpha-4(IV) chain / P53420* / collagen type IV alpha 4 chain*	/ complex / -
ENSMUSG00000031274	Col4a5 / collagen, type IV, alpha 5 / P29400* / collagen type IV alpha 5 chain*	/ - / complex
ENSMUSG00000079465	Col4a3 / Q9QZS0 / Collagen alpha-3(IV) chain Tumstatin / Q01955* / collagen type IV alpha 3 chain*	/ -

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr