ENSMUSG00000031274


Mus musculus

Features
Gene ID: ENSMUSG00000031274
  
Biological name :Col4a5
  
Synonyms : Col4a5 / collagen, type IV, alpha 5
  
Possible biological names infered from orthology : collagen type IV alpha 5 chain / P29400
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F2
Gene start: 141475385
Gene end: 141689234
  
Corresponding Affymetrix probe sets: 10602105 (MoGene1.0st)   1425475_at (Mouse Genome 430 2.0 Array)   1425476_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108552
Ensembl peptide - ENSMUSP00000108553
Ensembl peptide - ENSMUSP00000116610
NCBI entrez gene - 12830     See in Manteia.
MGI - MGI:88456
RefSeq - XM_017318372
RefSeq - NM_001163155
RefSeq - NM_007736
RefSeq - XM_006528696
RefSeq - XM_006528697
RefSeq Peptide - NP_001156627
RefSeq Peptide - NP_031762
swissprot - Q63ZW6
swissprot - F7CK55
Ensembl - ENSMUSG00000031274
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col4a5ENSDARG00000052063Danio rerio
 COL4A5ENSGALG00000008141Gallus gallus
 COL4A5ENSG00000188153Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*ENSMUSG0000003150261
Col4a3 / Q9QZS0 / Collagen alpha-3(IV) chain Tumstatin / Q01955* / collagen type IV alpha 3 chain*ENSMUSG0000007946555
Col4a4 / Q9QZR9 / Collagen alpha-4(IV) chain / P53420* / collagen type IV alpha 4 chain*ENSMUSG0000006715848
Col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*ENSMUSG0000003127348
Col4a2 / P08122 / Collagen alpha-2(IV) chain Canstatin / P08572* / collagen type IV alpha 2 chain*ENSMUSG0000003150346
Col22a1 / collagen, type XXII, alpha 1 / Q8NFW1* / collagen type XXII alpha 1 chain*ENSMUSG0000007902234
Q8BLX7 / Col16a1 / Collagen alpha-1(XVI) chain / Q07092* / collagen type XVI alpha 1 chain*ENSMUSG0000004069033
Q0VF58 / Col19a1 / Collagen alpha-1(XIX) chain / Q14993* / collagen type XIX alpha 1 chain*ENSMUSG0000002614125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001442  Collagen IV, non-collagenous
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR016187  C-type lectin fold
 IPR036954  Collagen IV, non-collagenous domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005587 collagen type IV trimer IDA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0031594 neuromuscular junction IDA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Non-integrin membrane-ECM interactions
NCAM1 interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0003236 abnormal lens capsule morphology "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1op/Csf1op
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a2tm1b(EUCOMM)Wtsi/Col1a2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col1a2tm1b(EUCOMM)Wtsi/Bay

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0011483 renal glomerular synechia "presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

 MP:0011509 dilated glomerular capillary "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079465 Col4a3 / Q9QZS0 / Collagen alpha-3(IV) chain Tumstatin / Q01955* / collagen type IV alpha 3 chain*  / - / complex
 ENSMUSG00000031273 Col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*  / complex / -
 ENSMUSG00000031274 Col4a5 / collagen, type IV, alpha 5 / P29400* / collagen type IV alpha 5 chain*  / complex / -
 ENSMUSG00000067158 Col4a4 / Q9QZR9 / Collagen alpha-4(IV) chain / P53420* / collagen type IV alpha 4 chain*  / - / complex
 ENSMUSG00000031503 Col4a2 / P08122 / Collagen alpha-2(IV) chain Canstatin / P08572* / collagen type IV alpha 2 chain*  / -
 ENSMUSG00000031502 Col4a1 / P02463 / Collagen alpha-1(IV) chain Arresten / P02462* / collagen type IV alpha 1 chain*  / -






 

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