ENSDARG00000052063


Danio rerio

Features
Gene ID: ENSDARG00000052063
  
Biological name :col4a5
  
Synonyms : col4a5 / collagen, type IV, alpha 5 (Alport syndrome)
  
Possible biological names infered from orthology : collagen, type IV, alpha 5 / collagen type IV alpha 5 chain / P29400
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 51103232
Gene end: 51194430
  
Corresponding Affymetrix probe sets: Dr.23827.1.A1_at (Zebrafish Array)   Dr.23827.1.A1_s_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068317
Ensembl peptide - ENSDARP00000143110
NCBI entrez gene - 323561     See in Manteia.
RefSeq - NM_001123230
RefSeq - XM_021477401
RefSeq Peptide - NP_001116702
swissprot - B0UXF7
swissprot - A0A1L1QZI9
ZFIN ID - ZDB-GENE-030131-2281
Ensembl - ENSDARG00000052063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COL4A5ENSGALG00000008141Gallus gallus
 COL4A5ENSG00000188153Homo sapiens
 Col4a5ENSMUSG00000031274Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
col4a1 / collagen, type IV, alpha 1 / P02462* / P02463* / collagen type IV alpha 1 chain* / Collagen alpha-1(IV) chain Arresten*ENSDARG0000005500954
col4a3 / collagen, type IV, alpha 3 / Q01955* / Q9QZS0* / collagen type IV alpha 3 chain* / Collagen alpha-3(IV) chain Tumstatin*ENSDARG0000000339546
col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*ENSDARG0000005206146
col4a2 / collagen, type IV, alpha 2 / P08122* / P08572* / collagen type IV alpha 2 chain* / Collagen alpha-2(IV) chain Canstatin*ENSDARG0000010411043
col4a4 / collagen, type IV, alpha 4 / Q9QZR9* / P53420* / Collagen alpha-4(IV) chain * / collagen type IV alpha 4 chain*ENSDARG0000000283142
col16a1 / collagen, type XVI, alpha 1 / Q8BLX7* / Q07092* / Collagen alpha-1(XVI) chain * / collagen type XVI alpha 1 chain*ENSDARG0000000919429
col19a1 / collagen, type XIX, alpha 1ENSDARG0000007616315
zmp:0000000760ENSDARG0000007474513
si:dkey-117n7.4ENSDARG0000009206411
si:ch211-106n13.3ENSDARG0000005263310
col21a1 / collagen, type XXI, alpha 1 / Q96P44* / collagen type XXI alpha 1 chain*ENSDARG000000253209
si:dkey-225n22.4ENSDARG000000772453


Protein motifs (from Interpro)
Interpro ID Name
 IPR001442  Collagen IV, non-collagenous
 IPR008160  Collagen triple helix repeat
 IPR016187  C-type lectin fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007412 axon target recognition IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0048846 axon extension involved in axon guidance IMP
 biological_processGO:0071711 basement membrane organization IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005604 basement membrane IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Non-integrin membrane-ECM interactions
NCAM1 interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain basement membrane spatial pattern , abnormal
hindbrain basement membrane irregular spatial pattern , abnormal
hindbrain basement membrane organization decreased process quality , abnormal
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 ZFA:0000152 retina retina quality , abnormal
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 ZFA:0000252 optic tract optic tract disorganized , abnormal
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 ZFA:0000445 optic tectum optic tectum basement membrane deformed , abnormal
optic tectum extracellular matrix deformed , abnormal
optic tectum radial glial cell deformed , abnormal
optic tectum basement membrane spatial pattern , abnormal
optic tectum basement membrane irregular spatial pattern , abnormal
optic tectum basement membrane organization decreased process quality , abnormal
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 ZFA:0001691 cerebellar granule cell cerebellar granule cell axon extension involved in axon guidance decreased process quality , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell retinal ganglion cell axon guidance decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104110 col4a2 / collagen, type IV, alpha 2 / P08122* / P08572* / collagen type IV alpha 2 chain* / Collagen alpha-2(IV) chain Canstatin*  / -
 ENSDARG00000052061 col4a6 / collagen, type IV, alpha 6 / Q14031* / collagen type IV alpha 6 chain*  / - / complex
 ENSDARG00000002831 col4a4 / collagen, type IV, alpha 4 / Q9QZR9* / P53420* / Collagen alpha-4(IV) chain * / collagen type IV alpha 4 chain*  / - / complex
 ENSDARG00000052063 col4a5 / collagen, type IV, alpha 5 (Alport syndrome) / P29400* / collagen, type IV, alpha 5* / collagen type IV alpha 5 chain*  / - / complex






 

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