ENSMUSG00000034282


Mus musculus

Features
Gene ID: ENSMUSG00000034282
  
Biological name :Evpl
  
Synonyms : Envoplakin / Evpl / Q9D952
  
Possible biological names infered from orthology : Q92817
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116220559
Gene end: 116238077
  
Corresponding Affymetrix probe sets: 10393197 (MoGene1.0st)   1419133_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037850
NCBI entrez gene - 14027     See in Manteia.
MGI - MGI:107507
RefSeq - NM_025276
RefSeq - XM_017314254
RefSeq Peptide - NP_079552
swissprot - Q9D952
Ensembl - ENSMUSG00000034282
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 evplaENSDARG00000019808Danio rerio
 EVPLENSGALG00000002108Gallus gallus
 EVPLENSG00000167880Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppl / periplakin / O60437*ENSMUSG0000003945726
Plec / Q9QXS1 / plectin / Q15149*ENSMUSG0000002256523
Dst / Q91ZU6 / Dystonin / Q03001*ENSMUSG0000002613119
Macf1 / microtubule-actin crosslinking factor 1 / Q9UPN3*ENSMUSG0000002864919
Dsp / E9Q557 / Desmoplakin / P15924*ENSMUSG0000005488919
Eppk1 / epiplakin 1ENSMUSG0000011538810


Protein motifs (from Interpro)
Interpro ID Name
 IPR001101  Plectin repeat
 IPR018159  Spectrin/alpha-actinin
 IPR030460  Envoplakin
 IPR035915  Plakin repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0018149 peptide cross-linking ISO
 biological_processGO:0030216 keratinocyte differentiation ISO
 biological_processGO:0031424 keratinization IEA
 cellular_componentGO:0001533 cornified envelope ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0005198 structural molecule activity ISO
 molecular_functionGO:0019215 intermediate filament binding IEA
 molecular_functionGO:0030674 protein binding, bridging ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049128 Ivl / involucrin / P07476*  / complex
 ENSMUSG00000039457 Ppl / periplakin / O60437*  / complex / reaction
 ENSMUSG00000022218 Tgm1 / transglutaminase 1 / P22735*  / complex






 

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