ENSG00000167880


Homo sapiens

Features
Gene ID: ENSG00000167880
  
Biological name :EVPL
  
Synonyms : envoplakin / EVPL / Q92817
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 76004502
Gene end: 76027452
  
Corresponding Affymetrix probe sets: 204503_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301607
Ensembl peptide - ENSP00000465630
Ensembl peptide - ENSP00000467717
NCBI entrez gene - 2125     See in Manteia.
OMIM - 601590
RefSeq - NM_001988
RefSeq - NM_001320747
RefSeq Peptide - NP_001307676
RefSeq Peptide - NP_001979
swissprot - Q92817
swissprot - K7EKI0
swissprot - K7EQ87
Ensembl - ENSG00000167880
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 evplaENSDARG00000019808Danio rerio
 EVPLENSGALG00000002108Gallus gallus
 EvplENSMUSG00000034282Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPL / O60437 / periplakinENSG0000011889826
PLEC / Q15149 / plectinENSG0000017820924
DSP / P15924 / desmoplakinENSG0000009669619
MACF1 / Q9UPN3 / microtubule-actin crosslinking factor 1ENSG0000012760318
DST / Q03001 / dystoninENSG0000015191417
EVPLL / A8MZ36 / envoplakin likeENSG0000021486011
EPPK1 / epiplakin 1ENSG0000026115011


Protein motifs (from Interpro)
Interpro ID Name
 IPR001101  Plectin repeat
 IPR018159  Spectrin/alpha-actinin
 IPR030460  Envoplakin
 IPR035915  Plakin repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0018149 peptide cross-linking IDA
 biological_processGO:0030216 keratinocyte differentiation IDA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0001533 cornified envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0019215 intermediate filament binding IEA
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118898 PPL / O60437 / periplakin  / complex / reaction
 ENSG00000163207 IVL / P07476 / involucrin  / complex
 ENSG00000092295 TGM1 / P22735 / transglutaminase 1  / complex






 

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