ENSG00000163207


Homo sapiens

Features
Gene ID: ENSG00000163207
  
Biological name :IVL
  
Synonyms : involucrin / IVL / P07476
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 152908545
Gene end: 152911886
  
Corresponding Affymetrix probe sets: 214599_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357753
NCBI entrez gene - 3713     See in Manteia.
OMIM - 147360
RefSeq - NM_005547
RefSeq Peptide - NP_005538
swissprot - P07476
Ensembl - ENSG00000163207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IvlENSMUSG00000049128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000354  Involucrin repeat
 IPR019571  Involucrin, N-terminal
 IPR019743  Involucrin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010224 response to UV-B IDA
 biological_processGO:0018149 peptide cross-linking IDA
 biological_processGO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine TAS
 biological_processGO:0030216 keratinocyte differentiation IDA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0001533 cornified envelope IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005198 structural molecule activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030674 protein binding, bridging IDA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092295 TGM1 / P22735 / transglutaminase 1  / complex / reaction
 ENSG00000167880 EVPL / Q92817 / envoplakin  / complex
 ENSG00000118898 PPL / O60437 / periplakin  / complex






 

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contact: otassy@igbmc.fr