ENSG00000118898


Homo sapiens

Features
Gene ID: ENSG00000118898
  
Biological name :PPL
  
Synonyms : O60437 / periplakin / PPL
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 4882507
Gene end: 4960741
  
Corresponding Affymetrix probe sets: 203407_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340510
Ensembl peptide - ENSP00000465640
Ensembl peptide - ENSP00000467699
NCBI entrez gene - 5493     See in Manteia.
OMIM - 602871
RefSeq - XM_017023375
RefSeq - NM_002705
RefSeq - XM_006720902
RefSeq - XM_017023374
RefSeq Peptide - NP_002696
swissprot - O60437
swissprot - K7EQ71
swissprot - K7EKI8
Ensembl - ENSG00000118898
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pplENSDARG00000101043Danio rerio
 PPLENSGALG00000002201Gallus gallus
 PplENSMUSG00000039457Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EVPL / Q92817 / envoplakinENSG0000016788030
PLEC / Q15149 / plectinENSG0000017820922
DST / Q03001 / dystoninENSG0000015191419
MACF1 / Q9UPN3 / microtubule-actin crosslinking factor 1ENSG0000012760318
DSP / P15924 / desmoplakinENSG0000009669617
EPPK1 / epiplakin 1ENSG000002611509
EVPLL / A8MZ36 / envoplakin likeENSG000002148604


Protein motifs (from Interpro)
Interpro ID Name
 IPR001101  Plectin repeat
 IPR018159  Spectrin/alpha-actinin
 IPR035915  Plakin repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0009612 response to mechanical stimulus IEP
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0001533 cornified envelope TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005200 structural constituent of cytoskeleton TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope
Butyrophilin (BTN) family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000026950 BTN3A1 / O00481 / butyrophilin subfamily 3 member A1  / reaction / complex
 ENSG00000124557 BTN1A1 / Q13410 / butyrophilin subfamily 1 member A1  / reaction / complex
 ENSG00000167880 EVPL / Q92817 / envoplakin  / complex / reaction
 ENSG00000163207 IVL / P07476 / involucrin  / complex
 ENSG00000189337 KAZN / Q674X7 / kazrin, periplakin interacting protein  / complex / reaction
 ENSG00000092295 TGM1 / P22735 / transglutaminase 1  / complex






 

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