| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0000420 | ruffled hair | "fuzzy, irregular appearance of the hair" [J:50844] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001231 | abnormal basal cell layer morphology | "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001236 | abnormal spinous layer morphology | "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001511 | disheveled coat | "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0001675 | abnormal ectoderm development | "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001685 | abnormal endoderm development | "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001874 | acanthosis | "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0002074 | abnormal hair texture | "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Efnb3lltw/Efnb3lltw
Genetic Background: involves: C3H/HeSnJ * C57BL/6J
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002578 | impaired ability to fire action potentials | "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ildr1tm1(KOMP)Wtsi/Ildr1tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N
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| MP:0002651 | abnormal sciatic nerve | "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ildr1tm1(KOMP)Wtsi/Ildr1tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N
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| MP:0002946 | delayed axon outgrowth | "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ildr1tm1(KOMP)Wtsi/Ildr1tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N
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| MP:0002952 | ventricular cardiomyopathy | "diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0003085 | abnormal egg cylinder morphology | "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0003137 | abnormal impulse conducting system conduction | "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0003566 | abnormal cell adhesion | "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0003809 | abnormal hair shaft morphology | "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0003812 | abnormal hair medulla | "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0004091 | abnormal Z lines | "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0004220 | abnormal peripheral nervous system regeneration | "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ildr1tm1(KOMP)Wtsi/Ildr1tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N
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| MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
Allelic Composition: Dsprul/Dsp+
Genetic Background: RB156Bnr/Ei-Dsprul/GrsrJ
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| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0006267 | abnormal intercalated disc morphology | "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0008022 | dilated heart ventricles | "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0008725 | enlarged heart atrium | "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0008767 | abnormal hair medullary septa cells | "septa-forming cells of hair medulla are abnormal in size or arrangement" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0008814 | reduced nerve conduction velocity | "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ildr1tm1(KOMP)Wtsi/Ildr1tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N
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| MP:0009594 | abnormal corneocyte envelope morphology | "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0009732 | ventricular premature beat | "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010234 | abnormal vibrissa follicle morphology | "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010505 | abnormal T wave | "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0010506 | prolonged RR interval | "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0010508 | abnormal heart electrocardiography waveform feature | "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0010546 | abnormal subendocardium layer morphology | "any structural anomaly of the layer of loose fibrous tissue located between the endocardium and myocardium which contains the nerves and the impulse-conducting system (Purkinje fibers) of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010636 | bundle branch block | "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011160 | dermal-epidermal separation | "the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis" [MGI:csmith] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0011919 | abnormal R wave | "any anomaly in the R wave which represents ventricular depolarization and corresponds to electrical impulses rather than mechanical ventricular contractions; irregular or multiple R waves may indicate arrhythmia and the shape of the R waves may indicate ventricular problems" [MPD:Molly] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0011925 | abnormal heart echocardiography feature | "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly] |
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Allelic Composition: Dsprul/Dsp+
Genetic Background: RB156Bnr/Ei-Dsprul/GrsrJ
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| MP:0012515 | abnormal heart apex morphology | "any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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| MP:0030520 | oral mucosa blisters | "localized pockets of fluid that form within or beneath the oral mucosa; may appear as pustules, vesicles, or bullae; color varies according to content of blister, which may include blood, serum, mucin, or suppuration" [https://books.google.com/books?isbn=0470673966, https://medical-dictionary.thefreedictionary.com/blisterform+oral+lesions] |
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Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB
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