ENSMUSG00000022074


Mus musculus

Features
Gene ID: ENSMUSG00000022074
  
Biological name :Tnfrsf10b
  
Synonyms : Q9QZM4 / Tnfrsf10b / Tumor necrosis factor receptor superfamily member 10B
  
Possible biological names infered from orthology : O00220 / O14763 / O14798 / Q9UBN6 / TNF receptor superfamily member 10a / TNF receptor superfamily member 10b / TNF receptor superfamily member 10c / TNF receptor superfamily member 10d / TNFRSF10A / TNFRSF10C / TNFRSF10D
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 69767472
Gene end: 69784411
  
Corresponding Affymetrix probe sets: 10416230 (MoGene1.0st)   1421296_at (Mouse Genome 430 2.0 Array)   1422344_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022663
NCBI entrez gene - 21933     See in Manteia.
MGI - MGI:1341090
RefSeq - NM_020275
RefSeq Peptide - NP_064671
swissprot - Q9QZM4
Ensembl - ENSMUSG00000022074
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdrENSDARG00000004392Danio rerio
 tnfrsfaENSDARG00000004451Danio rerio
 TNFRSF10BENSGALG00000000452Gallus gallus
 O00220ENSG00000104689Homo sapiens
 O14763ENSG00000120889Homo sapiens
 O14798ENSG00000173535Homo sapiens
 Q9UBN6ENSG00000173530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR020465  Tumour necrosis factor receptor 10
 IPR034024  Tumor necrosis factor receptor 10, N-terminal
 IPR034029  Tumour necrosis factor receptor 10A/B, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress ISS
 biological_processGO:0036462 TRAIL-activated apoptotic signaling pathway ISO
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process RCA
 molecular_functionGO:0045569 TRAIL binding RCA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / complex / reaction
 ENSMUSG00000039304 P50592 / Tnfsf10 / tumor necrosis factor (ligand) superfamily, member 10 / P50591* / TNF superfamily member 10*  / complex / reaction
 ENSMUSG00000022074 Q9QZM4 / Tnfrsf10b / Tumor necrosis factor receptor superfamily member 10B / O14798* / Q9UBN6* / O14763* / O00220* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member ...  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr