12370


Mus musculus (NCBI)

Features
Gene ID: 12370
  
Biological name :
  
Synonyms : Casp8 / CASP-8|FLICE|MACH|Mch5 / caspase 8
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1424552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 122056578
RefSeq - 33859520
RefSeq - 485050304
RefSeq - 568905658
RefSeq - NC_000067.6
RefSeq - NP_001073595.1
RefSeq - NP_001264855.1
RefSeq - NP_033942.1
RefSeq - XP_006495697.1
RefSeq - NM_001080126.1
RefSeq - NM_001277926.1
RefSeq - NM_009812.2
RefSeq - XM_006495634.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000026029 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0030225 macrophage differentiation TAS
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0036462 TRAIL-activated apoptotic signaling pathway ISO
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0045471 response to ethanol ISO
 biological_processGO:0045651 positive regulation of macrophage differentiation ISO
 biological_processGO:0045862 positive regulation of proteolysis ISO
 biological_processGO:0048738 cardiac muscle tissue development TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process ISO
 biological_processGO:0060546 negative regulation of necroptotic process IGI
 biological_processGO:0070243 regulation of thymocyte apoptotic process IGI
 biological_processGO:0097190 apoptotic signaling pathway ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0097194 execution phase of apoptosis ISO
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity ISO
 biological_processGO:0097284 hepatocyte apoptotic process IMP
 biological_processGO:1901216 positive regulation of neuron death ISO
 biological_processGO:2001233 regulation of apoptotic signaling pathway IGI
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion HDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030690 Noc1p-Noc2p complex IMP
 cellular_componentGO:0031264 death-inducing signaling complex ISO
 cellular_componentGO:0031265 CD95 death-inducing signaling complex ISO
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0044297 cell body ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0097342 ripoptosome ISO
 molecular_functionGO:0004175 endopeptidase activity IMP
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISO
 molecular_functionGO:0005123 death receptor binding ISO
 molecular_functionGO:0005164 tumor necrosis factor receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0035877 death effector domain binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044877 protein-containing complex binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0097110 scaffold protein binding ISO
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process ISO
 molecular_functionGO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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