ENSG00000121858


Homo sapiens

Features
Gene ID: ENSG00000121858
  
Biological name :TNFSF10
  
Synonyms : P50591 / TNFSF10 / TNF superfamily member 10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q26.31
Gene start: 172505508
Gene end: 172523507
  
Corresponding Affymetrix probe sets: 202687_s_at (Human Genome U133 Plus 2.0 Array)   202688_at (Human Genome U133 Plus 2.0 Array)   214329_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000241261
Ensembl peptide - ENSP00000389931
Ensembl peptide - ENSP00000404008
NCBI entrez gene - 8743     See in Manteia.
OMIM - 603598
RefSeq - NM_001190942
RefSeq - NM_003810
RefSeq Peptide - NP_001177871
RefSeq Peptide - NP_003801
swissprot - Q6IBA9
swissprot - P50591
swissprot - H7C246
Ensembl - ENSG00000121858
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf10ENSDARG00000057241Danio rerio
 TNFSF10ENSGALG00000009179Gallus gallus
 P50592ENSMUSG00000039304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14788 / TNFSF11 / TNF superfamily member 11ENSG0000012065922


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR017355  Tumour necrosis factor ligand 10/11
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IEA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120889 O14763 / TNFRSF10B / TNF receptor superfamily member 10b  / reaction / complex
 ENSG00000003402 CFLAR / O15519 / CASP8 and FADD like apoptosis regulator  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / reaction / complex
 ENSG00000104689 O00220 / TNFRSF10A / TNF receptor superfamily member 10a  / complex / reaction
 ENSG00000121858 P50591 / TNFSF10 / TNF superfamily member 10  / complex / reaction
 ENSG00000003400 CASP10 / Q92851 / caspase 10  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / reaction / complex






 

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